Evaluation of cefuroxime concentration in the intrathecal and extrathecal compartments of the lumbar spine-an experimental study in pigs.
CSF
cefuroxime
microdialysis
spinal cord
spine surgery
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
21
01
2023
received:
03
05
2022
accepted:
23
01
2023
medline:
12
6
2023
pubmed:
31
1
2023
entrez:
30
1
2023
Statut:
ppublish
Résumé
Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. Sufficient time above the minimal inhibitory concentration (fT > MIC) for relevant bacteria in target tissues is required for cefuroxime. We assessed cefuroxime concentrations and fT > MIC of 4 μg·ml Eight female pigs were anaesthetized and laminectomized at L3-L4. Microdialysis catheters were placed for sampling in the spinal cord, CSF, and epidural space. A single dose of 1500 mg cefuroxime was administered intravenously over 10 min. Microdialysates and plasma were obtained continuously during 8 h. Cefuroxime concentrations were determined by ultra-high-performance liquid chromatography. Mean fT > MIC (4 μg·ml fT > MIC (4 μg·ml
Sections du résumé
BACKGROUND AND PURPOSE
Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. Sufficient time above the minimal inhibitory concentration (fT > MIC) for relevant bacteria in target tissues is required for cefuroxime. We assessed cefuroxime concentrations and fT > MIC of 4 μg·ml
EXPERIMENTAL APPROACH
Eight female pigs were anaesthetized and laminectomized at L3-L4. Microdialysis catheters were placed for sampling in the spinal cord, CSF, and epidural space. A single dose of 1500 mg cefuroxime was administered intravenously over 10 min. Microdialysates and plasma were obtained continuously during 8 h. Cefuroxime concentrations were determined by ultra-high-performance liquid chromatography.
KEY RESULTS
Mean fT > MIC (4 μg·ml
CONCLUSION AND IMPLICATIONS
fT > MIC (4 μg·ml
Substances chimiques
Cefuroxime
O1R9FJ93ED
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1832-1842Informations de copyright
© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
Références
Alexander, S. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Amarosi, L., Anderson, C. M. H., Beart, P. M., Broer, S., Dawson, P. A., Hagenbuch, B., Hammond, J. R., Inui, K.-i., … Verri, T. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. British Journal of Pharmacology, 178(S1), S412-S513. https://doi.org/10.1111/bph.15543
Alluri, R., Kang, H. P., Bouz, G., Wang, J., & Hah, R. J. (2020). The true effect of a lumbar dural tear on complications and cost. Spine, 45(3), E155-E162. https://doi.org/10.1097/brs.0000000000003213
Avdeef, A. (2011). How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability? European Journal of Pharmaceutical Sciences, 43(3), 109-124. https://doi.org/10.1016/j.ejps.2011.04.001
Babic, M., & Simpfendorfer, C. S. (2017). Infections of the spine. Infectious Disease Clinics of North America, 31(2), 279-297. https://doi.org/10.1016/j.idc.2017.01.003
Bratzler, D. W., & Houck, P. M. (2005). Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project. American Journal of Surgery, 189(4), 395-404. https://doi.org/10.1016/j.amjsurg.2005.01.015
Bue, M., Thomassen, M. B., Larsen, O. H., Jørgensen, A. R., Stilling, M., Søballe, K., & Hanberg, P. (2021). Local vancomycin concentrations after intra-articular injection into the knee joint: An experimental porcine study. The Journal of Knee Surgery, 34(9), 936-940. https://doi.org/10.1055/s-0039-3402078
Busscher, I., Ploegmakers, J. J., Verkerke, G. J., & Veldhuizen, A. G. (2010). Comparative anatomical dimensions of the complete human and porcine spine. European Spine Journal, 19(7), 1104-1114. https://doi.org/10.1007/s00586-010-1326-9
Chan, C. T., & Gold, W. L. (1998). Intramedullary abscess of the spinal cord in the antibiotic era: Clinical features, microbial etiologies, trends in pathogenesis, and outcomes. Clinical Infectious Diseases, 27(3), 619-626. https://doi.org/10.1086/514699
Craig, W. A. (2003). Basic pharmacodynamics of antibacterials with clinical applications to the use of β-lactams, glycopeptides, and linezolid. Infectious Disease Clinics of North America, 17(3), 479-501. https://doi.org/10.1016/s0891-5520(03)00065-5
Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Patel, H. H., Sobey, C. G., Stanford, S. C., Stanley, P., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N., & Ahluwalia, A. (2022). Planning experiments: Updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology, 179, 3907-3913. https://doi.org/10.1111/bph.15868
Darouiche, R. O. (2006). Spinal epidural abscess. The New England Journal of Medicine, 355(19), 2012-2020. https://doi.org/10.1056/NEJMra055111
de Lange, E. C., & Danhof, M. (2002). Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: Implications of the barriers between blood and brain. Clinical Pharmacokinetics, 41(10), 691-703. https://doi.org/10.2165/00003088-200241100-00001
Drusano, G. L. (2004). Antimicrobial pharmacodynamics: Critical interactions of ‘bug and drug’. Nature Reviews. Microbiology, 2(4), 289-300. https://doi.org/10.1038/nrmicro862
European Committee on Antimicrobial Susceptibility Testing. (n.d.). EUCAST MIC distribution website. http://www.eucast.org
Greenlee, J. E. (2003). Subdural empyema. Current Treatment Options in Neurology, 5(1), 13-22. https://doi.org/10.1007/s11940-003-0019-7
Hamberger, A., Jacobson, I., Nyström, B., & Sandberg, M. (1991). Microdialysis sampling of the neuronal environment in basic and clinical research. Journal of Internal Medicine, 230(4), 375-380. https://doi.org/10.1111/j.1365-2796.1991.tb00460.x
Hanberg, P., Bue, M., Birke Sørensen, H., Søballe, K., & Tøttrup, M. (2016). Pharmacokinetics of single-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone determined by microdialysis. The Spine Journal, 16(3), 432-438. https://doi.org/10.1016/j.spinee.2015.11.031
Hanberg, P., Bue, M., Jørgensen, A. R., Thomassen, M., Öbrink-Hansen, K., Søballe, K., & Stilling, M. (2020). Pharmacokinetics of double-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone-A randomized microdialysis study. The Spine Journal, 20, 1327-1332. https://doi.org/10.1016/j.spinee.2020.03.006
Hanberg, P., Bue, M., Kabel, J., Jørgensen, A. R., Jessen, C., Søballe, K., & Stilling, M. (2021). Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue. Acta Orthopaedica, 92, 746-752. https://doi.org/10.1080/17453674.2021.1942620
Hanberg, P., Bue, M., Öbrink-Hansen, K., Kabel, J., Thomassen, M., Tøttrup, M., Søballe, K., & Stilling, M. (2020). Simultaneous retrodialysis by drug for cefuroxime using meropenem as an internal standard-A microdialysis validation study. Journal of Pharmaceutical Sciences, 109(3), 1373-1379. https://doi.org/10.1016/j.xphs.2019.11.014
Harun, S. N., Nordin, S. A., Gani, S. S. A., Shamsuddin, A. F., Basri, M., & Basri, H. B. (2018). Development of nanoemulsion for efficient brain parenteral delivery of cefuroxime: Designs, characterizations, and pharmacokinetics. International Journal of Nanomedicine, 13, 2571-2584. https://doi.org/10.2147/ijn.S151788
Hassanzadeh, H., Bell, J., Bhatia, M., & Puvanesarajah, V. (2021). Incidental durotomy in lumbar spine surgery; risk factors, complications, and perioperative management. The Journal of the American Academy of Orthopaedic Surgeons, 29(6), e279-e286. https://doi.org/10.5435/jaaos-d-20-00210
Hosmann, A., Ritscher, L. C., Burgmann, H., Oesterreicher, Z., Jäger, W., Poschner, S., Knosp, E., Reinprecht, A., Gruber, A., & Zeitlinger, M. (2018). Concentrations of cefuroxime in brain tissue of neurointensive care patients. Antimicrobial Agents and Chemotherapy, 62(2), e02164-17.https://doi.org/10.1128/aac.02164-17
Høy, K., Hansen, E. S., He, S. Z., Søballe, K., Henriksen, T. B., Kjølseth, D., Hjortdal, V., & Bünger, C. (1994). Regional blood flow, plasma volume, and vascular permeability in the spinal cord, the dural sac, and lumbar nerve roots. Spine, 19(24), 2804-2811. https://doi.org/10.1097/00007632-199412150-00013
Hvistendahl, M. A., Bue, M., Hanberg, P., Kaspersen, A. E., Schmedes, A. V., Stilling, M., & Høy, K. (2022). Cefuroxime concentrations in the anterior and posterior column of the lumbar spine-An experimental porcine study. The Spine Journal, 22, 1434-1441. https://doi.org/10.1016/j.spinee.2022.05.010
Hvistendahl, M. A., Hanberg, P., Stilling, M., Kaspersen, A. E., Høy, K., & Bue, M. (2022). Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: Results from a porcine microdialysis study. Acta Orthopaedica, 93, 874-879. https://doi.org/10.2340/17453674.2022.5276
Iwasaki, M., Yano, S., Aoyama, T., Hida, K., & Iwasaki, Y. (2011). Acute onset intramedullary spinal cord abscess with spinal artery occlusion: A case report and review. European Spine Journal, 20, 294-301. https://doi.org/10.1007/s00586-011-1703-z
Joukhadar, C., & Müller, M. (2005). Microdialysis: Current applications in clinical pharmacokinetic studies and its potential role in the future. Clinical Pharmacokinetics, 44(9), 895-913. https://doi.org/10.2165/00003088-200544090-00002
Kasiakou, S. K., Sermaides, G. J., Michalopoulos, A., Soteriades, E. S., & Falagas, M. E. (2005). Continuous versus intermittent intravenous administration of antibiotics: A meta-analysis of randomised controlled trials. The Lancet Infectious Diseases, 5(9), 581-589. https://doi.org/10.1016/s1473-3099(05)70218-8
Kenward, M. G., & Roger, J. H. (2009). An improved approximation to the precision of fixed effects from restricted maximum likelihood. Computational Statistics and Data Analysis, 53(7), 2583-2595. https://doi.org/10.1016/j.csda.2008.12.013
Knudsen, M., Bue, M., Pontoppidan, L. L., Hvistendahl, M. A., Søballe, K., Stilling, M., & Hanberg, P. (2021). Evaluation of benzylpenicillin as an internal standard for measurement of piperacillin bone concentrations via microdialysis. Journal of Pharmaceutical Sciences, 110(10), 3500-3506. https://doi.org/10.1016/j.xphs.2021.06.008
Kossmann, T., Hans, V., Stocker, R., Imhof, H. G., Joos, B., Trentz, O., & Morganti-Kossmann, M. C. (1996). Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury. The Journal of Antimicrobial Chemotherapy, 37(1), 161-167. https://doi.org/10.1093/jac/37.1.161
Laban, J. T., & O'Neill, K. (2009). CNS infection. Surgery, 27(3), 125-129. https://doi.org/10.1016/j.mpsur.2009.02.010
Lener, S., Hartmann, S., Barbagallo, G. M. V., Certo, F., Thomé, C., & Tschugg, A. (2018). Management of spinal infection: A review of the literature. Acta Neurochirurgica, 160(3), 487-496. https://doi.org/10.1007/s00701-018-3467-2
Li, Z., Liu, P., Zhang, C., Xu, G., Zhang, Y., Chang, Y., Liu, M., & Hou, S. (2019). Incidence, prevalence, and analysis of risk factors for surgical site infection after lumbar fusion surgery: ≥2-year follow-up retrospective study. World Neurosurgery, 131, e460-e467. https://doi.org/10.1016/j.wneu.2019.07.207
Lilley, E., Stanford, S. C., Kendall, D. E., Alexander, S. P. H., Cirino, G., Docherty, J. R., George, C. H., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Sobey, C. G., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2020). ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. British Journal of Pharmacology, 177(16), 3611-3616. https://doi.org/10.1111/bph.15178
Lin, T. Y., Chen, W. J., Hsieh, M. K., Lu, M. L., Tsai, T. T., Lai, P. L., Fu, T. S., Niu, C. C., & Chen, L. H. (2014). Postoperative meningitis after spinal surgery: A review of 21 cases from 20,178 patients. BMC Infectious Diseases, 14, 220. https://doi.org/10.1186/1471-2334-14-220
Martin, R. J., & Yuan, H. A. (1996). Neurosurgical care of spinal epidural, subdural, and intramedullary abscesses and arachnoiditis. The Orthopedic Clinics of North America, 27(1), 125-136. https://doi.org/10.1016/S0030-5898(20)32057-5
Mestre, H., Mori, Y., & Nedergaard, M. (2020). The brain's glymphatic system: Current controversies. Trends in Neurosciences, 43(7), 458-466. https://doi.org/10.1016/j.tins.2020.04.003
Müller, M. (2002). Science, medicine, and the future: Microdialysis. BMJ, 324(7337), 588-591. https://doi.org/10.1136/bmj.324.7337.588
Nau, R., Sörgel, F., & Eiffert, H. (2010). Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clinical Microbiology Reviews, 23(4), 858-883. https://doi.org/10.1128/cmr.00007-10
Oordt-Speets, A. M., Bolijn, R., van Hoorn, R. C., Bhavsar, A., & Kyaw, M. H. (2018). Global etiology of bacterial meningitis: A systematic review and meta-analysis. PLoS ONE, 13(6), e0198772. https://doi.org/10.1371/journal.pone.0198772
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., Garner, P., Holgate, S. T., Howells, D. W., Karp, N. A., Lazic, S. E., Lidster, K., MacCallum, C. J., Macleod, M., … Würbel, H. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biology, 18(7), e3000410. https://doi.org/10.1371/journal.pbio.3000410
Rimmler, C., Lanckohr, C., Akamp, C., Horn, D., Fobker, M., Wiebe, K., Redwan, B., Ellger, B., Koeck, R., & Hempel, G. (2019). Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis. British Journal of Clinical Pharmacology, 85(12), 2864-2877. https://doi.org/10.1111/bcp.14121
Rubin, D. B. (1976). Inference and missing data. Biometrika, 63(3), 581-592. https://doi.org/10.1093/biomet/63.3.581
Saleh, M. A. A., & de Lange, E. C. M. (2021). Impact of CNS diseases on drug delivery to brain extracellular and intracellular target sites in human: A “WHAT-IF” simulation study. Pharmaceutics, 13(1), 95. https://doi.org/10.3390/pharmaceutics13010095
Shaffer, W. O., Baisden, J. L., Fernand, R., & Matz, P. G. (2013). An evidence-based clinical guideline for antibiotic prophylaxis in spine surgery. The Spine Journal, 13(10), 1387-1392. https://doi.org/10.1016/j.spinee.2013.06.030
Shapiro, W. R., Young, D. F., & Mehta, B. M. (1975). Methotrexate: Distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections. The New England Journal of Medicine, 293(4), 161-166. https://doi.org/10.1056/nejm197507242930402
Stulberg, J. J., Delaney, C. P., Neuhauser, D. V., Aron, D. C., Fu, P., & Koroukian, S. M. (2010). Adherence to surgical care improvement project measures and the association with postoperative infections. Jama, 303(24), 2479-2485. https://doi.org/10.1001/jama.2010.841
Sullins, A. K., & Abdel-Rahman, S. M. (2013). Pharmacokinetics of antibacterial agents in the CSF of children and adolescents. Paediatric Drugs, 15(2), 93-117. https://doi.org/10.1007/s40272-013-0017-5
Tannenbaum, J., & Bennett, B. T. (2015). Russell and Burch's 3Rs then and now: The need for clarity in definition and purpose. Journal of the American Association for Laboratory Animal Science, 54(2), 120-132.
Tøstesen, S. K., Hanberg, P., Bue, M., Thillemann, T. M., Falstie-Jensen, T., Tøttrup, M., Knudsen, M. B., Schmedes, A. V., & Stilling, M. (2022). Weight-based cefuroxime dosing provides comparable orthopedic target tissue concentrations between weight groups-A microdialysis porcine study. APMIS, 130(2), 111-118. https://doi.org/10.1111/apm.13198
Tøttrup, M., Søballe, K., Bibby, B. M., Hardlei, T. F., Hansen, P., Fuursted, K., Birke-Sørensen, H., & Bue, M. (2019). Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients-A randomized controlled trial comparing continuous and short-term infusion. APMIS, 127(12), 779-788. https://doi.org/10.1111/apm.12996
Tsai, T. H., Cheng, F. C., Chen, K. C., Chen, Y. F., & Chen, C. F. (1999). Simultaneous measurement of cefuroxime in rat blood and brain by microdialysis and microbore liquid chromatography: Application to pharmacokinetics. Journal of Chromatography. B, Biomedical Sciences and Applications, 735(1), 25-31. https://doi.org/10.1016/s0378-4347(99)00410-7
Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., Maciejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., le, D., … Wilson, M. (2018). DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Research, 46(D1), D1074-D1082. https://doi.org/10.1093/nar/gkx1037
Zhou, J., Wang, R., Huo, X., Xiong, W., Kang, L., & Xue, Y. (2020). Incidence of surgical site infection after spine surgery: A systematic review and meta-analysis. Spine, 45(3), 208-216. https://doi.org/10.1097/brs.0000000000003218