Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus.
autonomic nervous system
blood pressure
microneurography
sympathetic activity
type 2 diabetes mellitus
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
11
2022
accepted:
30
12
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce. We studied 61 patients with type 2 diabetes mellitus (22 women, 60.9 ± 1.4 years; 39 men, 60.9 ± 1.4 years). They had to have diabetes for at least 2 years, a hemoglobin A1c of 6.5-10%, a body-mass-index of 20-40 kg/m MSNA was 37.5 ± 2.5 bursts/min in women and 39.0 ± 2.0 bursts/min in men ( We conclude that relatively few older patients with type 2 diabetes mellitus exhibit increased MSNA. The large interindividual variability in MSNA cannot be explained by gender, blood pressure, body mass index, or glycemic control.
Identifiants
pubmed: 36711125
doi: 10.3389/fnins.2022.1107752
pmc: PMC9878600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1107752Informations de copyright
Copyright © 2023 Heusser, Tank, Diedrich, Fischer, Heise and Jordan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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