New insights into the regulation of

Akt CBS DYRK1A GSK3β NF-κB pharmacological inhibitor

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2022
Historique:
received: 28 11 2022
accepted: 19 12 2022
entrez: 30 1 2023
pubmed: 31 1 2023
medline: 31 1 2023
Statut: epublish

Résumé

Down syndrome (DS), the most frequent chromosomic aberration, results from the presence of an extra copy of chromosome 21. The identification of genes which overexpression contributes to intellectual disability (ID) in DS is important to understand the pathophysiological mechanisms involved and develop new pharmacological therapies. In particular, gene dosage of

Identifiants

pubmed: 36711154
doi: 10.3389/fnins.2022.1110163
pmc: PMC9879293
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1110163

Informations de copyright

Copyright © 2023 Conan, Léon, Caroff, Rollet, Chaïr, Martin, Bihel, Mignen, Voisset and Friocourt.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Pierre Conan (P)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Alice Léon (A)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Noéline Caroff (N)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Claire Rollet (C)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Loubna Chaïr (L)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Jennifer Martin (J)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Frédéric Bihel (F)

Laboratoire d'Innovation Thérapeutique, UMR 7200, IMS MEDALIS, Faculty of Pharmacy, CNRS, Université de Strasbourg, Illkirch, France.

Olivier Mignen (O)

U1227, Lymphocytes B, Autoimmunité et Immunothérapies, INSERM, Université de Brest, Brest, France.

Cécile Voisset (C)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Gaëlle Friocourt (G)

INSERM, Université de Brest, EFS, UMR 1078, GGB, Brest, France.

Classifications MeSH