Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives.
Automated mitochondrial analysis
MSC-Based therapies
Mesenchymal stem cells
Microfluidic systems
Mitochondrial dynamics
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
21
10
2022
revised:
03
01
2023
accepted:
11
01
2023
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
As centre of energy production and key regulators of metabolic and cellular signaling pathways, the integrity of mitochondria is essential for mesenchymal stem cell function in tissue regeneration. Alterations in the size, shape and structural organization of mitochondria are correlated with the physiological state of the cell and its environment and could be used as diagnostic biomarkers. Therefore, high-throughput experimental and computational techniques are crucial to ensure adequate correlations between mitochondrial function and disease phenotypes. The emerge of microfluidic technologies can address the shortcomings of traditional methods to determine mitochondrial dimensions for diagnostic and therapeutic use. This review discusses optical detection methods compatible with microfluidics to measure mitochondrial dynamics and their potential for clinical stem cell research targeting mitochondrial dysfunction.
Identifiants
pubmed: 36711314
doi: 10.1016/j.heliyon.2023.e12987
pii: S2405-8440(23)00194-9
pmc: PMC9873686
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e12987Informations de copyright
© 2023 The Authors.
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