The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
11 Jan 2023
11 Jan 2023
Historique:
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
The modification of lipopolysaccharide (LPS) in Although antibiotic prescriptions are guided by well-established susceptibility testing methods, antibiotic treatments oftentimes fail. The presented work is significant, because it uncovers a mechanism by which bacteria transiently avoid killing by antibiotics. This mechanism involves two closely related transcription factors, PmrA and QseB, which are conserved across Enterobacteriaceae. We demonstrate that PmrA and QseB share regulatory targets in lipid A modification pathway and prove that QseB can orchestrate modifications of lipid A in
Identifiants
pubmed: 36711705
doi: 10.1101/2023.01.10.523522
pmc: PMC9882033
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI048689
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107052
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129940
Pays : United States
Organisme : NIDDK NIH HHS
ID : P50 DK064540
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150098
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138576
Pays : United States
Organisme : NIDDK NIH HHS
ID : P20 DK123967
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI143244
Pays : United States
Commentaires et corrections
Type : UpdateIn
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