Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
10 Jan 2023
Historique:
entrez: 30 1 2023
pubmed: 31 1 2023
medline: 31 1 2023
Statut: epublish

Résumé

Hypoxia, an important feature of solid tumors, is a major factor shaping the immune landscape, and several cancer models have been developed to emulate hypoxic tumors. However, to date, they still have several limitations, such as the lack of reproducibility, inadequate biophysical cues, limited immune cell infiltration, and poor oxygen (O

Identifiants

pubmed: 36711715
doi: 10.1101/2023.01.10.523477
pmc: PMC9882080
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIBIB NIH HHS
ID : R01 EB027705
Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Thibault Colombani (T)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.

Zachary J Rogers (ZJ)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.

Khushbu Bhatt (K)

Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United States.

James Sinoimeri (J)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.

Lauren Gerbereux (L)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.

Mohammad Hamrangsekachaee (M)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.

Sidi A Bencherif (SA)

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, United States of America.
Department of Bioengineering, Northeastern University, Boston, MA 02115, United States of America.
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, United States of America.
Biomechanics and Bioengineering (BMBI), UTC CNRS UMR 7338, University of Technology of Compiègne, Sorbonne University, 60203 Compiègne, France.

Classifications MeSH