Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study.
cardiorespiratory fitness
inherited cardiac arrythmia
long QT syndrome
muscle fitness
pediatrics
physical activity
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
10
2022
accepted:
28
12
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
In children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions In this prospective, controlled, cross-sectional study, 20 children with LQTS (12.7 ± 3.7 years old) and 20 healthy controls (11.9 ± 2.4 years old) were enrolled. All participants underwent a cardiopulmonary exercise test, a muscular architecture ultrasound assessment, (cross-sectional area on right rectus femoris and pennation angle), a handgrip muscular strength evaluation, and a standing long broad jump test. The level of physical activity was determined using with a waist-worn tri-axial accelerometer (Actigraph GT3X). Peak oxygen uptake (VO Despite similar physical activity level, cardiorespiratory fitness and muscle fitness in children with LQTS were lower than in healthy controls. The origin of this limitation seemed to be multifactorial, involving beta-blocker induced chronotropic limitation, physical and muscle deconditioning. Cardiovascular rehabilitation could be of interest in children with LQTS with significant physical limitation.
Sections du résumé
Background
UNASSIGNED
In children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions
Materials and methods
UNASSIGNED
In this prospective, controlled, cross-sectional study, 20 children with LQTS (12.7 ± 3.7 years old) and 20 healthy controls (11.9 ± 2.4 years old) were enrolled. All participants underwent a cardiopulmonary exercise test, a muscular architecture ultrasound assessment, (cross-sectional area on right rectus femoris and pennation angle), a handgrip muscular strength evaluation, and a standing long broad jump test. The level of physical activity was determined using with a waist-worn tri-axial accelerometer (Actigraph GT3X).
Results
UNASSIGNED
Peak oxygen uptake (VO
Conclusion
UNASSIGNED
Despite similar physical activity level, cardiorespiratory fitness and muscle fitness in children with LQTS were lower than in healthy controls. The origin of this limitation seemed to be multifactorial, involving beta-blocker induced chronotropic limitation, physical and muscle deconditioning. Cardiovascular rehabilitation could be of interest in children with LQTS with significant physical limitation.
Identifiants
pubmed: 36712265
doi: 10.3389/fcvm.2022.1081106
pmc: PMC9874118
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1081106Informations de copyright
Copyright © 2023 Souilla, Avesani, Boisson, Requirand, Matecki, Vincenti, Werner, De La Villeon, Pommier, Pasquie, Guillaumont and Amedro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Circulation. 2004 Jun 8;109(22):2807-16
pubmed: 15184297
Circulation. 2015 Jul 7;132(1):10-9
pubmed: 25977310
J Strength Cond Res. 2010 Jul;24(7):1810-7
pubmed: 20555277
Br J Sports Med. 2011 Sep;45(11):849-58
pubmed: 21836169
J Biol Chem. 1967 May 10;242(9):2278-82
pubmed: 4290225
J Appl Physiol (1985). 1993 Jun;74(6):2740-4
pubmed: 8365975
Health Qual Life Outcomes. 2021 Jul 28;19(1):187
pubmed: 34321045
Int J Environ Res Public Health. 2020 Jun 04;17(11):
pubmed: 32512767
Neurol Sci. 2004 Oct;25(4):238-40
pubmed: 15549512
J Sci Med Sport. 2013 Jan;16(1):40-4
pubmed: 22749938
Arch Cardiovasc Dis. 2021 Nov;114(11):727-736
pubmed: 34756533
Med Sci Sports Exerc. 1990 Oct;22(5):605-14
pubmed: 2233199
Pediatr Cardiol. 2017 Aug;38(6):1206-1214
pubmed: 28608149
Eur Heart J. 2005 Jul;26(14):1422-45
pubmed: 15923204
Qual Health Res. 2011 Feb;21(2):278-91
pubmed: 20935236
Pediatr Cardiol. 2015 Dec;36(8):1588-601
pubmed: 26024647
Ultrasound Med Biol. 2017 Mar;43(3):586-594
pubmed: 28063610
J Physiol. 2021 Feb;599(3):737-767
pubmed: 33112439
J Electromyogr Kinesiol. 1999 Dec;9(6):401-5
pubmed: 10597053
Lancet. 2012 Jul 21;380(9838):219-29
pubmed: 22818936
J Am Heart Assoc. 2017 Sep 21;6(9):
pubmed: 28935680
Am Heart J. 1975 Mar;89(3):378-90
pubmed: 234667
J Appl Physiol (1985). 1994 Jun;76(6):2461-6
pubmed: 7928871
Lancet. 2020 Dec 5;396(10265):1780-1782
pubmed: 33248019
Eur Heart J. 2021 Jan 1;42(1):17-96
pubmed: 32860412
Circulation. 2009 Nov 3;120(18):1761-7
pubmed: 19841298
Br J Sports Med. 2013 Jan;47(1):28-33
pubmed: 23193325
Circ Res. 1986 Feb;58(2):281-91
pubmed: 3948345
J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):628-34
pubmed: 6706770
J Am Heart Assoc. 2017 Mar 6;6(3):
pubmed: 28264859
J Am Coll Cardiol. 2005 Apr 19;45(8):1318-21
pubmed: 15837280
Lancet Child Adolesc Health. 2020 Jan;4(1):23-35
pubmed: 31761562
Fed Proc. 1986 Dec;45(13):2924-9
pubmed: 3536591
BMC Pediatr. 2019 Jan 8;19(1):12
pubmed: 30621667
Int J Environ Res Public Health. 2020 Oct 31;17(21):
pubmed: 33142693
Public Health Rep. 1985 Mar-Apr;100(2):126-31
pubmed: 3920711
J Sports Sci. 2008 Dec;26(14):1557-65
pubmed: 18949660
J Am Coll Cardiol. 2003 Dec 3;42(11):1959-63
pubmed: 14662259
Circulation. 2020 Aug 18;142(7):e101-e118
pubmed: 32686505
Eur J Sport Sci. 2014;14(1):91-9
pubmed: 24533499
Quant Imaging Med Surg. 2020 Aug;10(8):1699-1722
pubmed: 32742962
Med Sci Sports Exerc. 2011 Feb;43(2):357-64
pubmed: 20581716
J Appl Physiol (1985). 1986 Jun;60(6):2020-7
pubmed: 3087938
Acta Physiol Scand Suppl. 1984;536:1-53
pubmed: 6151777
Am J Cardiol. 1991 Jun 15;67(16):1405-12
pubmed: 2042572
Med Sci Sports Exerc. 2002 Mar;34(3):456-63
pubmed: 11880810
Eur J Pediatr. 2010 Mar;169(3):281-7
pubmed: 19526369
Sports Med. 2014 Sep;44(9):1209-23
pubmed: 24788950
Circulation. 2015 Dec 1;132(22):e326-9
pubmed: 26527716
Cardiol Young. 2015 Mar;25(3):501-10
pubmed: 24607033
Clin Nutr. 2019 Oct;38(5):2002-2015
pubmed: 31031136
Arch Dis Child. 2007 Jun;92(6):509-14
pubmed: 17307794
Int J Behav Nutr Phys Act. 2013 Aug 15;10:98
pubmed: 23945179
Eur Heart J. 2009 Dec;30(23):2915-20
pubmed: 19692392
JACC Heart Fail. 2018 Jan;6(1):30-40
pubmed: 29284578
Heart. 2018 Jun;104(12):1026-1036
pubmed: 29170358
Arch Dis Child. 2020 Nov;105(11):1035-1040
pubmed: 32198161
Int J Cardiol. 2019 May 15;283:112-118
pubmed: 30616811
Muscle Nerve. 2013 Jun;47(6):856-63
pubmed: 23519831
Acta Paediatr. 2021 Jan;110(1):280-287
pubmed: 32420673
Eur J Prev Cardiol. 2022 Sep 7;29(12):1630-1632
pubmed: 35708716
Br J Sports Med. 2016 Dec;50(23):1451-1458
pubmed: 27670254
Lancet. 2008 Aug 30;372(9640):750-63
pubmed: 18761222