Successful treatment of acute pancreatitis associated with late-onset acute liver GVHD after second allogeneic hematopoietic cell transplantation.
acute graft-versus-host disease (GVHD)
acute pancreatitis
corticosteroids
tacrolimus
Journal
Blood cell therapy
ISSN: 2432-7026
Titre abrégé: Blood Cell Ther
Pays: Japan
ID NLM: 9918333884906676
Informations de publication
Date de publication:
25 Aug 2022
25 Aug 2022
Historique:
received:
01
11
2021
accepted:
14
02
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
We report the case of a 28-year-old woman who developed upper abdominal pain and jaundice after a second unrelated allogeneic hematopoietic cell transplantation (allo-HCT) for acute lymphoid leukemia (ALL). Laboratory data showed elevated levels of liver enzymes, amylase, and lipase. Although acute pancreatitis was suspected, no structural lesions were detected. Liver biopsy was compatible with late-onset acute graft-versus-host disease (GVHD), which resolved following treatment with methylprednisolone (mPSL) and tacrolimus (TAC). In addition, her serum amylase level and abdominal pain rapidly resolved following acute GVHD-directed therapy. Acute pancreatitis concomitant with late-onset acute liver GVHD is extremely rare and has not been documented subsequent to a second allo-HCT.
Identifiants
pubmed: 36712552
doi: 10.31547/bct-2021-023
pmc: PMC9873419
doi:
Types de publication
Case Reports
Langues
eng
Pagination
79-82Informations de copyright
Copyright Ⓒ2022 Asia-Pacific Blood and Marrow Transplantation Group (APBMT).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. Disclosure forms provided by the authors are available on the website.
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