IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy.
EGFR
IL-1
PD1 (programmed cell death protein 1)
immunotherapy
moab
senescence
senotherapeutics
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
10
2022
accepted:
19
12
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion of inflammatory components, known as senescence-associated secretory phenotype (SASP). However, recent reports demonstrated that anti-cancer therapy itself can stimulate a senescence response in tumor cells, the so-called therapy-induced senescence (TIS), which may represent a temporary bypass pathway that promotes drug resistance. In this context, several studies have shown that EGFR blockage, by TKIs or moAbs, promotes TIS by increasing IL-1 cytokine production, thus pushing cells into a "pseudo-senescent" state. Today, senotherapeutic agents are emerging as a potential strategy in cancer treatment thanks to their dual role in annihilating senescent cells and simultaneously preventing their awakening into a resistant and aggressive form. Here, we summarize classic and recent findings about the cellular processes driving senescence and SASP, and we provide a state-of-the-art of the anti-cancer strategies available so far that exploits the activation and/or blockade of senescence-based mechanisms.
Identifiants
pubmed: 36712972
doi: 10.3389/fcell.2022.1083743
pii: 1083743
pmc: PMC9877625
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1083743Informations de copyright
Copyright © 2023 Romaniello, Gelfo, Pagano, Sgarzi, Morselli, Girone, Filippini, D’Uva and Lauriola.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Genes Dev. 2007 Apr 15;21(8):879-85
pubmed: 17437994
Cancers (Basel). 2020 Aug 24;12(9):
pubmed: 32847130
Cancers (Basel). 2020 Mar 29;12(4):
pubmed: 32235364
Mol Cell Biol. 2013 Aug;33(16):3242-58
pubmed: 23775115
Cancer Lett. 2021 Jul 10;510:79-92
pubmed: 33878394
Biochem Biophys Res Commun. 2015 May 22;461(1):28-34
pubmed: 25858318
Annu Rev Pathol. 2010;5:99-118
pubmed: 20078217
Nat Rev Cancer. 2008 Jul;8(7):512-22
pubmed: 18574463
Cell. 2019 Oct 31;179(4):813-827
pubmed: 31675495
Methods Mol Biol. 2019;1904:11-51
pubmed: 30539465
Nature. 2006 Nov 30;444(7119):638-42
pubmed: 17136094
Exp Gerontol. 1999 Dec;34(8):911-21
pubmed: 10673145
Nat Rev Immunol. 2010 Aug;10(8):554-67
pubmed: 20616810
Curr Pharm Des. 2013;19(9):1680-98
pubmed: 23061726
Science. 2022 Oct 14;378(6616):192-201
pubmed: 36227993
Nat Immunol. 2012 Mar 18;13(4):343-51
pubmed: 22430787
Biochem Pharmacol. 2015 Aug 15;96(4):337-48
pubmed: 26093063
J Immunother Cancer. 2019 Mar 19;7(1):79
pubmed: 30890189
Cancers (Basel). 2018 Sep 26;10(10):
pubmed: 30261609
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Lancet Oncol. 2016 May;17(5):577-89
pubmed: 27083334
Cell Rep. 2019 Oct 1;29(1):104-117.e4
pubmed: 31577941
Cancer Cell. 2018 Apr 9;33(4):785
pubmed: 29634951
Cancer Discov. 2022 Nov 2;12(11):2666-2683
pubmed: 35895872
Front Cell Dev Biol. 2021 Oct 07;9:754069
pubmed: 34692707
Cell. 2010 Jun 25;141(7):1117-34
pubmed: 20602996
Nat Rev Mol Cell Biol. 2001 Feb;2(2):127-37
pubmed: 11252954
Cell Res. 2018 Jul;28(7):775-778
pubmed: 29872106
Curr Biol. 2017 Sep 11;27(17):2652-2660.e4
pubmed: 28844647
Oncotarget. 2016 Nov 1;7(44):72167-72183
pubmed: 27708224
Cancer Res. 2011 Oct 1;71(19):6261-9
pubmed: 21852385
PLoS Biol. 2010 Sep 07;8(9):
pubmed: 20838657
Nature. 2018 Jan 4;553(7686):96-100
pubmed: 29258294
Cancer Res. 2007 Feb 1;67(3):1062-71
pubmed: 17283139
Nature. 1972 Jul 7;238(5358):26-30
pubmed: 12635262
Cancers (Basel). 2021 Jan 27;13(3):
pubmed: 33513872
N Engl J Med. 2018 Jan 11;378(2):113-125
pubmed: 29151359
EBioMedicine. 2019 Feb;40:554-563
pubmed: 30616998
EMBO Mol Med. 2021 Apr 9;13(4):e13144
pubmed: 33660397
Trends Cell Biol. 2007 Nov;17(11):529-36
pubmed: 17980599
Curr Pharm Des. 2017;23(32):4893-4905
pubmed: 28606052
Front Oncol. 2018 May 18;8:164
pubmed: 29868482
Science. 2000 May 26;288(5470):1425-9
pubmed: 10827953
Cell Rep. 2018 Apr 24;23(4):1205-1219
pubmed: 29694896
FEBS J. 2021 Jan;288(1):56-80
pubmed: 32961620
Aging Cell. 2015 Aug;14(4):644-58
pubmed: 25754370
PLoS Biol. 2008 Dec 2;6(12):2853-68
pubmed: 19053174
Cell Mol Biol Lett. 2022 Mar 2;27(1):20
pubmed: 35236282
Mol Cell Biol. 2000 Sep;20(18):6741-54
pubmed: 10958672
J Natl Cancer Inst. 1994 Sep 7;86(17):1303-14
pubmed: 7520508
Trends Biochem Sci. 2006 Jul;31(7):402-10
pubmed: 16774833
Annu Rev Biochem. 2015;84:739-64
pubmed: 25621509
Nature. 2003 Jul 10;424(6945):219-23
pubmed: 12853963
Int J Biochem Cell Biol. 2005 May;37(5):961-76
pubmed: 15743671
Cell. 2020 Apr 16;181(2):424-441.e21
pubmed: 32234521
Sci Rep. 2016 Aug 02;6:30842
pubmed: 27480406
EMBO Mol Med. 2019 Dec;11(12):e10234
pubmed: 31746100
Cancers (Basel). 2019 Feb 08;11(2):
pubmed: 30743996
Cell. 2013 Oct 10;155(2):462-77
pubmed: 24120142
J UOEH. 2019;41(2):153-163
pubmed: 31292359
Cell Rep. 2018 Dec 26;25(13):3706-3720.e8
pubmed: 30590043
J Immunol. 2013 Apr 1;190(7):3500-9
pubmed: 23475218
Cancers (Basel). 2017 May 17;9(5):
pubmed: 28513565
Front Mol Biosci. 2020 May 13;7:63
pubmed: 32478091
Sci Rep. 2019 Apr 11;9(1):5912
pubmed: 30976015
Oncogene. 2001 Aug 23;20(37):5100-10
pubmed: 11526498
J Clin Oncol. 2017 Oct 20;35(30):3484-3515
pubmed: 28806116
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888
pubmed: 29432166
Nat Commun. 2017 Feb 23;8:14532
pubmed: 28230051
Br J Cancer. 1997;75(4):593-6
pubmed: 9052416
Future Oncol. 2022 Sep;18(27):3085-3100
pubmed: 36004638
Physiol Rev. 2016 Jul;96(3):1025-1069
pubmed: 33003261
J Natl Cancer Inst. 2010 Oct 20;102(20):1536-46
pubmed: 20858887
J Exp Clin Cancer Res. 2016 Sep 27;35(1):153
pubmed: 27670139
Cell Rep. 2017 Oct 17;21(3):773-783
pubmed: 29045843
Front Cell Dev Biol. 2021 Mar 29;9:645593
pubmed: 33855023
J Immunol. 2021 Apr 15;206(8):1966-1975
pubmed: 33722878
Oncotarget. 2018 May 1;9(33):23058-23077
pubmed: 29796172
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7
pubmed: 7568133
Oncol Rep. 2007 Feb;17(2):313-7
pubmed: 17203166
Cancers (Basel). 2022 Oct 01;14(19):
pubmed: 36230739
EMBO J. 2003 Aug 15;22(16):4212-22
pubmed: 12912919
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1361-1369
pubmed: 30545915
Immun Ageing. 2020 Jan 20;17:2
pubmed: 31988649
Cancer Cell. 2008 Jul 8;14(1):79-89
pubmed: 18598946
J Clin Invest. 2018 Apr 2;128(4):1247-1254
pubmed: 29608140
Science. 2019 Dec 20;366(6472):1473-1480
pubmed: 31699882
Curr Drug Targets. 2016;17(4):460-6
pubmed: 26302802
PLoS Genet. 2012;8(5):e1002650
pubmed: 22654667
Cell Rep. 2021 Jul 27;36(4):109441
pubmed: 34320349
Biochem Biophys Res Commun. 2019 May 21;513(1):219-225
pubmed: 30952434
J Clin Oncol. 2000 Feb;18(4):904-14
pubmed: 10673534
Cancer Treat Rev. 2017 Nov;60:60-68
pubmed: 28889085
Nat Commun. 2018 Apr 30;9(1):1723
pubmed: 29712904
Aging Cell. 2020 Dec;19(12):e13270
pubmed: 33166065
Mol Cell. 2008 May 9;30(3):267-76
pubmed: 18471973
Aging Cell. 2012 Aug;11(4):569-78
pubmed: 22404905
Int J Mol Sci. 2020 Aug 20;21(17):
pubmed: 32825489
Cell. 2013 Nov 21;155(5):1104-18
pubmed: 24238962
Curr Oncol Rep. 2016 Aug;18(8):47
pubmed: 27287329
Nat Cell Biol. 2019 Jan;21(1):94-101
pubmed: 30602768
Oncotarget. 2016 Nov 15;7(46):76087-76100
pubmed: 27738319
Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95
pubmed: 33328614
Exp Cell Res. 1961 Dec;25:585-621
pubmed: 13905658
Lancet. 2017 Oct 21;390(10105):1833-1842
pubmed: 28855077
Front Immunol. 2019 Sep 25;10:2247
pubmed: 31608061
Exp Cell Res. 2003 Mar 10;284(1):31-53
pubmed: 12648464
Nat Commun. 2016 Apr 06;7:11190
pubmed: 27048913
iScience. 2020 Dec 30;24(1):102016
pubmed: 33490922
Nat Cell Biol. 2013 Aug;15(8):978-90
pubmed: 23770676
Nature. 2003 Nov 13;426(6963):194-8
pubmed: 14608368
Nature. 1990 May 31;345(6274):458-60
pubmed: 2342578
Biochem Pharmacol. 2019 Apr;162:202-212
pubmed: 30576620