Durability analysis of the highly effective mRNA-1273 vaccine against COVID-19.
COVID-19
SARS-CoV-2
mRNA-1273
vaccine durability
vaccine effectiveness
Journal
PNAS nexus
ISSN: 2752-6542
Titre abrégé: PNAS Nexus
Pays: England
ID NLM: 9918367777906676
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
22
01
2022
accepted:
17
05
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
COVID-19 vaccines are effective, but breakthrough infections have been increasingly reported. We conducted a test-negative case-control study to assess the durability of protection against symptomatic infection after vaccination with mRNA-1273. We fit conditional logistic regression (CLR) models stratified on residential county and calendar date of SARS-CoV-2 PCR testing to assess the association between the time elapsed since vaccination and the odds of symptomatic infection, adjusted for several covariates. There were 2,364 symptomatic individuals who had a positive SARS-CoV-2 PCR test after full vaccination with mRNA-1273 ("cases") and 12,949 symptomatic individuals who contributed 15,087 negative tests after full vaccination ("controls"). The odds of symptomatic infection were significantly higher 250 days after full vaccination compared to the date of full vaccination (Odds Ratio [OR]: 2.47, 95% confidence interval [CI]: 1.19-5.13). The odds of non-COVID-19 associated hospitalization and non-COVID-19 pneumonia (negative control outcomes) remained relatively stable over the same time interval (Day 250 OR
Identifiants
pubmed: 36713311
doi: 10.1093/pnasnexus/pgac058
pii: pgac058
pmc: PMC9802296
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pgac058Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences.
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