Engineering a self-eliminating transgene in the yellow fever mosquito,
Aedes aegypti
DNA repair
genetically modified organisms
genome editing
single-strand annealing
Journal
PNAS nexus
ISSN: 2752-6542
Titre abrégé: PNAS Nexus
Pays: England
ID NLM: 9918367777906676
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
20
01
2022
accepted:
22
03
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
Promising genetics-based approaches are being developed to reduce or prevent the transmission of mosquito-vectored diseases. Less clear is how such transgenes can be removed from the environment, a concern that is particularly relevant for highly invasive gene drive transgenes. Here, we lay the groundwork for a transgene removal system based on single-strand annealing (SSA), a eukaryotic DNA repair mechanism. An SSA-based rescuer strain (
Identifiants
pubmed: 36713320
doi: 10.1093/pnasnexus/pgac037
pii: pgac037
pmc: PMC9802104
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pgac037Subventions
Organisme : NIAID NIH HHS
ID : R01 AI148787
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences.
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