Pravastatin in preeclampsia: A meta-analysis and systematic review.
intrauterine growth restriction (IUGR)
meta-analysis
neonatal intensive care unit (NICU)
pravastatin
preeclampsia
prevention
statin
systematic review
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
10
2022
accepted:
30
12
2022
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
To review of the efficacy and safety of pravastatin use for prophylaxis and treatment of preeclampsia. Systematic review and meta-analysis of clinical studies evaluating pravastatin for treatment and/or prophylaxis of preeclampsia. Two independent reviewers systematically searched data from PubMed, Scopus, Web of Science, Cochrane, Embase, and clinicaltrials.gov databases, for studies evaluating pravastatin for prevention of pre-eclampsia. Fourteen studies were identified, including 1,570 pregnant women who received either pravastatin or placebo, published between 2003 and 2022. From these studies, 5 studies were identified for inclusion in the meta-analysis to evaluate the role of pravastatin use prior to 20 weeks of gestation, to prevent pre-eclampsia, Pravastatin treatment reduced the incidence of preeclampsia by 61% and premature birth by 45%. Among the newborns, there was a 45% reduction in intrauterine growth retardation (IUGR) in the treated group, as well as a 77% reduction in those receiving neonatal intensive care unit (NICU) admissions. Prophylactic treatment with pravastatin appears to reduce risk of developing pre-eclampsia as well as potentially lowering risk of IUGR, preterm birth, and NICU admission in neonates.
Identifiants
pubmed: 36714131
doi: 10.3389/fmed.2022.1076372
pmc: PMC9880057
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
1076372Informations de copyright
Copyright © 2023 Mészáros, Veres, Nagyistók, Somogyi, Rosta, Herold, Kukor and Valent.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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