A new and efficient procedure to load bioactive molecules within the human heavy-chain ferritin nanocage.
disassembly/reassembly nanocage protocols
drug encapsulation
ferritin nanocages
human ferritin nanocarriers
reversible ferritin disassembly
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
08
2022
accepted:
02
01
2023
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
epublish
Résumé
For their easy and high-yield recombinant production, their high stability in a wide range of physico-chemical conditions and their characteristic hollow structure, ferritins (Fts) are considered useful scaffolds to encapsulate bioactive molecules. Notably, for the absence of immunogenicity and the selective interaction with tumor cells, the nanocages constituted by the heavy chain of the human variant of ferritin (hHFt) are optimal candidates for the delivery of anti-cancer drugs. hHFt nanocages can be disassembled and reassembled
Identifiants
pubmed: 36714262
doi: 10.3389/fmolb.2023.1008985
pii: 1008985
pmc: PMC9880187
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1008985Informations de copyright
Copyright © 2023 Lucignano, Stanzione, Ferraro, Di Girolamo, Cané, Di Somma, Duilio, Merlino and Picone.
Déclaration de conflit d'intérêts
A patent application on the procedure deposited by RL, IS, CC, ADS, AD, and DP is pending (deposit number 102022000012728). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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