Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation.
Molar excess volume
Natural deep eutectic systems
Raman spectroscopy
Thermal analysis
Water activity
Journal
Journal of molecular liquids
ISSN: 0167-7322
Titre abrégé: J Mol Liq
Pays: Netherlands
ID NLM: 9882716
Informations de publication
Date de publication:
01 Feb 2023
01 Feb 2023
Historique:
pmc-release:
01
02
2024
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
ppublish
Résumé
Natural Deep Eutectic Systems (NADES) composed of sugar and sugar alcohols have been studied and applied in a variety of biological applications. Understanding their interaction with water across dilution and temperature is inherently important for maximizing the utility of NADES. Herein a wide range of sugar:sugar-alcohol molar ratios were synthesized and characterized by viscosity, molar excess volume, differential scanning calorimetry, water activity, and confocal Raman cryomicroscopy. NADES were found to have greater viscosity, reduced heat of fusion, greater absolute molar excess volume, lower water activity, and stronger hydrogen bonding of water than non-NADES mixtures. This is hypothesized to be due to cumulatively stronger hydrogen bonding interactions between components in pure and diluted NADES with the strongest interactions in the water-rich region. This work provides useful data and further understanding of hydrogen bonding interaction strength for a wide range of molar ratios in pure to well-diluted forms.
Identifiants
pubmed: 36714523
doi: 10.1016/j.molliq.2022.120937
pmc: PMC9879365
mid: NIHMS1861954
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL154734
Pays : United States
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