Bipolar spectrum disorders are associated with increased gray matter volume in the medial orbitofrontal cortex and nucleus accumbens.
bipolar spectrum disorder
frontostriatal
gray matter volume
male
reward
risk
Journal
JCPP advances
ISSN: 2692-9384
Titre abrégé: JCPP Adv
Pays: United States
ID NLM: 9918250414706676
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
entrez:
30
1
2023
pubmed:
31
1
2023
medline:
31
1
2023
Statut:
ppublish
Résumé
Elevated sensitivity to rewards prospectively predicts Bipolar Spectrum Disorder (BSD) onset; however, it is unclear whether volumetric abnormalities also reflect BSD risk. BSDs emerge when critical neurodevelopment in frontal and striatal regions occurs in sex-specific ways. The current paper examined the volume of frontal and striatal brain regions in both individuals with and at risk for a BSD with exploratory analyses examining sex-specificity. One hundred fourteen medication-free individuals ages 18-27 at low-risk for BSD (moderate-reward sensitivity; The BSD group had enlarged frontostriatal volumes (mOFC, NAcc) compared to low individuals ( An enlarged frontostriatal volume (averaged mOFC, NAcc) is associated with the presence of a BSD, while subvolumes (mOFC vs. NAcc) showed unique patterning in relation to risk. We report preliminary evidence that sex moderates frontostriatal volume in BSD, highlighting the need for larger longitudinal risk studies examining the role of sex-specific neurodevelopmental trajectories in emerging BSDs.
Identifiants
pubmed: 36714682
doi: 10.1002/jcv2.12068
pmc: PMC9879263
mid: NIHMS1863053
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH102310
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH126368
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH077908
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH126911
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100117
Pays : United States
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST The authors have declared that they have no competing or potential conflicts of interest.
Références
Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20750-20759
pubmed: 31548375
Bipolar Disord. 2009 Mar;11(2):135-44
pubmed: 19267696
Neuroimage. 2016 Nov 1;141:273-281
pubmed: 27453157
Child Dev. 2009 Mar-Apr;80(2):327-37
pubmed: 19466995
Clin Psychol Rev. 2005 Feb;25(2):241-62
pubmed: 15642648
J Neurosci. 2013 Oct 9;33(41):16383-93
pubmed: 24107968
Neuropsychopharmacology. 2010 Jul;35(8):1743-50
pubmed: 20357761
Curr Dir Psychol Sci. 2010 Jun 1;19(3):189-194
pubmed: 20606725
J Psychiatr Res. 2003 Jul-Aug;37(4):297-303
pubmed: 12765852
Neuropsychopharmacology. 2010 Jan;35(1):4-26
pubmed: 19812543
Neuroimage. 2017 Jan 15;145(Pt B):246-253
pubmed: 27421184
Neuroscience. 2009 Nov 24;164(1):331-43
pubmed: 19358880
J Clin Psychiatry. 2009 Apr 21;70(5):699-705
pubmed: 19389332
Dev Cogn Neurosci. 2018 Oct;33:27-41
pubmed: 28774477
J Psychiatry Neurosci. 2016 Jun;41(4):240-50
pubmed: 26645741
J Affect Disord. 1985 May-Jun;8(3):233-41
pubmed: 3160735
Mol Psychiatry. 2017 Oct;22(10):1455-1463
pubmed: 27217146
Bipolar Disord. 2008 Mar;10(2):310-22
pubmed: 18271911
J Neurosci. 2017 May 17;37(20):5065-5073
pubmed: 28432144
J Affect Disord. 2015 Jul 15;180:90-6
pubmed: 25885066
J Abnorm Psychol. 2012 Feb;121(1):16-27
pubmed: 21668080
Biol Psychiatry. 2004 Mar 15;55(6):648-51
pubmed: 15013835
Bipolar Disord. 2012 May;14(3):249-60
pubmed: 22548898
Curr Dir Psychol Sci. 2013 Apr 1;22(2):121-127
pubmed: 24761055
Am J Psychiatry. 2003 May;160(5):999-1001
pubmed: 12727708
Clin Psychol Rev. 2008 Oct;28(7):1188-205
pubmed: 18565633
JCPP Adv. 2022 Mar;2(1):
pubmed: 36714682
Annu Rev Clin Psychol. 2015;11:213-50
pubmed: 25581235
Am J Psychiatry. 2009 Jul;166(7):795-804
pubmed: 19448190
Soc Cogn Affect Neurosci. 2015 Jan;10(1):106-13
pubmed: 24526186
Behav Res Ther. 2014 Nov;62:74-87
pubmed: 25241675
Clin Psychol Psychother. 2012 Jul-Aug;19(4):352-62
pubmed: 22610999
J Am Acad Child Adolesc Psychiatry. 2017 Jan;56(1):67-78
pubmed: 27993231
J Affect Disord. 2005 Mar;85(1-2):181-9
pubmed: 15780688
Biol Sex Differ. 2012 Aug 21;3(1):19
pubmed: 22908911
Front Neurosci. 2016 Dec 06;10:558
pubmed: 27999528
Am J Psychiatry. 2002 Nov;159(11):1841-7
pubmed: 12411217
Nat Rev Neurosci. 2005 Sep;6(9):691-702
pubmed: 16136173
Nat Rev Neurosci. 2008 Dec;9(12):947-57
pubmed: 19002191
J Abnorm Psychol. 2012 Aug;121(3):592-601
pubmed: 22775582
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Neuroimage. 2014 Mar;88:242-51
pubmed: 24121203
J Abnorm Psychol. 2012 May;121(2):339-351
pubmed: 22004113
Sci Rep. 2020 Jul 31;10(1):12953
pubmed: 32737332
J Affect Disord. 2017 Jul;216:3-16
pubmed: 28237133
J Am Acad Child Adolesc Psychiatry. 2010 Feb;49(2):162-72.e1-5
pubmed: 20215938
J Psychopathol Behav Assess. 2001 Sep 1;23(3):133-143
pubmed: 21765592
Int J Cogn Ther. 2009;2(2):176-187
pubmed: 20360995
Biol Psychiatry. 2012 Mar 15;71(6):552-60
pubmed: 22281121
Biol Psychiatry. 2005 Apr 1;57(7):733-42
pubmed: 15820230
Brain Cogn. 2014 Aug;89:15-26
pubmed: 24512818
Behav Ther. 2016 Sep;47(5):600-621
pubmed: 27816074
Bipolar Disord. 2004 Feb;6(1):43-52
pubmed: 14996140
Front Aging Neurosci. 2014 Oct 07;6:264
pubmed: 25339897
J Affect Disord. 2002 Apr;68(2-3):167-81
pubmed: 12063145
J Psychiatr Res. 2012 Oct;46(10):1267-71
pubmed: 22858352
Biol Psychiatry. 2010 Jul 1;68(1):41-50
pubmed: 20609836
Neurosci Lett. 2002 Aug 30;329(2):243-5
pubmed: 12165422
J Affect Disord. 1999 Aug;54(3):319-28
pubmed: 10467978
Neurosci Lett. 2009 May 29;456(1):44-8
pubmed: 19429131
Arch Gen Psychiatry. 1978 Jul;35(7):837-44
pubmed: 678037
Am J Psychiatry. 2013 Nov;170(11):1285-96
pubmed: 24185241
Arch Gen Psychiatry. 2004 Oct;61(10):974-84
pubmed: 15466670
Neuroimage. 2012 Aug 15;62(2):774-81
pubmed: 22248573