Extracellular vesicle fusion visualized by cryo-electron microscopy.


Journal

PNAS nexus
ISSN: 2752-6542
Titre abrégé: PNAS Nexus
Pays: England
ID NLM: 9918367777906676

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 01 04 2022
revised: 30 06 2022
accepted: 09 08 2022
entrez: 30 1 2023
pubmed: 31 1 2023
medline: 31 1 2023
Statut: epublish

Résumé

Extracellular vesicles (EVs) transfer bioactive molecules between cells in a process reminiscent of enveloped viruses. EV cargo delivery is thought to occur by protein-mediated and pH-dependent membrane fusion of the EV and the cellular membrane. However, there is a lack of methods to identify the fusion proteins and resolve their mechanism. We developed and benchmarked an

Identifiants

pubmed: 36714848
doi: 10.1093/pnasnexus/pgac156
pii: pgac156
pmc: PMC9802263
doi:

Types de publication

Journal Article

Langues

eng

Pagination

pgac156

Informations de copyright

© The Author(s) 2022. Published by Oxford University Press on behalf of the National Academy of Sciences.

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Auteurs

Mattia I Morandi (MI)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Petro Busko (P)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Efrat Ozer-Partuk (E)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Suman Khan (S)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Giulia Zarfati (G)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Yael Elbaz-Alon (Y)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Paula Abou Karam (P)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Tina Napso Shogan (T)

Faculty of Health, Bar Ilan University, Ramat-Gan 5290002, Israel.

Lana Ginini (L)

Faculty of Health, Bar Ilan University, Ramat-Gan 5290002, Israel.

Ziv Gil (Z)

Faculty of Health, Bar Ilan University, Ramat-Gan 5290002, Israel.
Head and Neck Center, Holy Family Hospital, Nazareth 1641100, Israel.

Neta Regev-Rudzki (N)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Ori Avinoam (O)

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.

Classifications MeSH