Milk Calcium and Phosphorus in Ugandan Women with HIV on Tenofovir-Based Antiretroviral Therapy.
Africa
HIV
Uganda
antiretroviral therapy (ART)
lactation
milk composition
mother-to-child transmission
tenofovir
Journal
Journal of human lactation : official journal of International Lactation Consultant Association
ISSN: 1552-5732
Titre abrégé: J Hum Lact
Pays: United States
ID NLM: 8709498
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
medline:
20
4
2023
pubmed:
31
1
2023
entrez:
30
1
2023
Statut:
ppublish
Résumé
Breastfed infants depend on human milk calcium and phosphorus for bone mineral accretion and growth. We reported greater mobilization of bone mineral and delayed skeletal recovery in lactating Ugandan women with HIV initiated on tenofovir-based antiretroviral therapy during pregnancy compared to HIV-uninfected counterparts in the Gumba Study. However, it is unknown if these disruptions in maternal bone metabolism affect milk mineral concentrations. To compare concentrations and patterns of change in milk calcium and phosphorus between lactating women with and without HIV. A longitudinal observational study was conducted to compare milk mineral concentrations between women with HIV receiving tenofovir-based ART and uninfected women in the Gumba Study. Milk collected at 2, 14, 26, and 52 weeks lactation was analyzed for calcium and phosphorus. Sodium and potassium were measured at 2 and 14 weeks to detect sub-clinical mastitis. Differences in milk composition between 84 women with HIV and 81 uninfected women were investigated. Women with HIV had higher milk calcium than uninfected women at 14 weeks. The percent difference was +10.2% ( Participants with HIV on tenofovir-based antiretroviral therapy had altered milk mineral composition. Studies are needed to investigate mechanisms and health implications for the woman and infant.
Sections du résumé
BACKGROUND
Breastfed infants depend on human milk calcium and phosphorus for bone mineral accretion and growth. We reported greater mobilization of bone mineral and delayed skeletal recovery in lactating Ugandan women with HIV initiated on tenofovir-based antiretroviral therapy during pregnancy compared to HIV-uninfected counterparts in the Gumba Study. However, it is unknown if these disruptions in maternal bone metabolism affect milk mineral concentrations.
RESEARCH AIM
To compare concentrations and patterns of change in milk calcium and phosphorus between lactating women with and without HIV.
METHODS
A longitudinal observational study was conducted to compare milk mineral concentrations between women with HIV receiving tenofovir-based ART and uninfected women in the Gumba Study. Milk collected at 2, 14, 26, and 52 weeks lactation was analyzed for calcium and phosphorus. Sodium and potassium were measured at 2 and 14 weeks to detect sub-clinical mastitis. Differences in milk composition between 84 women with HIV and 81 uninfected women were investigated.
RESULTS
Women with HIV had higher milk calcium than uninfected women at 14 weeks. The percent difference was +10.2% (
CONCLUSIONS
Participants with HIV on tenofovir-based antiretroviral therapy had altered milk mineral composition. Studies are needed to investigate mechanisms and health implications for the woman and infant.
Identifiants
pubmed: 36715180
doi: 10.1177/08903344221146472
pmc: PMC10115928
doi:
Substances chimiques
Tenofovir
99YXE507IL
Calcium
SY7Q814VUP
Phosphorus
27YLU75U4W
Minerals
0
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
288-299Références
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