Clinical relevance of macroglossia to disease progression in ventilation dependent patients with advanced ALS.
Amyotrophic lateral sclerosis
Body mass index
Communication impairment
Invasive ventilation
Macroglossia
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
26
10
2022
accepted:
24
01
2023
medline:
15
5
2023
pubmed:
31
1
2023
entrez:
30
1
2023
Statut:
ppublish
Résumé
Macroglossia is one of the clinical signs that emerges in patients with amyotrophic lateral sclerosis (ALS) who are undergoing invasive ventilation. We aimed to investigate the relationship between the progression of macroglossia and the clinical characteristics during the advanced stages of ALS. Forty-one patients with ALS using invasive ventilation with tracheostomy were prospectively followed over a 3-year period. We evaluated the prevalence of macroglossia, motor disabilities including oral function, communication ability (communication stage I to V) as a marker of disease progression, and nutritional factors. We analyzed the potential factors affecting the progression of macroglossia using a multivariate logistic analysis. The number of patients with macroglossia was increased during the follow-up (from 24.4 to 53.7%), while the communication stage progressed from 2.6 in average (SD 1.7) to 3.5 (1.4). During the study, body weight increased, while energy intake decreased, suggesting progressive hypometabolism. Eight patients had newly developed macroglossia during the study and showed greater progression of communication impairment than those without macroglossia. Multivariate logistic regression analysis showed that communication impairment was a factor associated with macroglossia. Macroglossia in advanced ALS with invasive ventilation is associated with disease progression.
Sections du résumé
BACKGROUND
BACKGROUND
Macroglossia is one of the clinical signs that emerges in patients with amyotrophic lateral sclerosis (ALS) who are undergoing invasive ventilation.
OBJECTIVE
OBJECTIVE
We aimed to investigate the relationship between the progression of macroglossia and the clinical characteristics during the advanced stages of ALS.
METHODS
METHODS
Forty-one patients with ALS using invasive ventilation with tracheostomy were prospectively followed over a 3-year period. We evaluated the prevalence of macroglossia, motor disabilities including oral function, communication ability (communication stage I to V) as a marker of disease progression, and nutritional factors. We analyzed the potential factors affecting the progression of macroglossia using a multivariate logistic analysis.
RESULTS
RESULTS
The number of patients with macroglossia was increased during the follow-up (from 24.4 to 53.7%), while the communication stage progressed from 2.6 in average (SD 1.7) to 3.5 (1.4). During the study, body weight increased, while energy intake decreased, suggesting progressive hypometabolism. Eight patients had newly developed macroglossia during the study and showed greater progression of communication impairment than those without macroglossia. Multivariate logistic regression analysis showed that communication impairment was a factor associated with macroglossia.
CONCLUSION
CONCLUSIONS
Macroglossia in advanced ALS with invasive ventilation is associated with disease progression.
Identifiants
pubmed: 36715782
doi: 10.1007/s10072-023-06646-7
pii: 10.1007/s10072-023-06646-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2025-2031Subventions
Organisme : Japan Society for the Promotion of Science
ID : 16K12054
Organisme : Japan Society for the Promotion of Science
ID : 19K10896
Informations de copyright
© 2023. Fondazione Società Italiana di Neurologia.
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