Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks.

Humans Antineoplastic Agents Antioxidants / pharmacology Cations / pharmacology Ferric Compounds Mitochondria Neuroblastoma

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
09 02 2023
Historique:
pubmed: 31 1 2023
medline: 11 2 2023
entrez: 30 1 2023
Statut: ppublish

Résumé

Although the lipophilic triphenylphosphonium (TPP

Identifiants

DOI: 10.1021/acs.jmedchem.2c01630 PMID: 36716281
pubmed: 36716281
doi: 10.1021/acs.jmedchem.2c01630
doi:

Substances chimiques

Antineoplastic Agents 0
Antioxidants 0
Cations 0
Ferric Compounds 0
triphenylphosphonium 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1835-1851

Auteurs

Sofia Benfeito (S)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
ORCID: 0000-0001-9645-8152

Carlos Fernandes (C)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
ORCID: 0000-0002-0102-0703

Daniel Chavarria (D)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
ORCID: 0000-0002-7010-9808

Sandra Barreiro (S)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
Associate Laboratory i4HB─Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
UCIBIO─Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Fernando Cagide (F)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
ORCID: 0000-0001-9410-6874

Lisa Sequeira (L)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.

José Teixeira (J)

CNC─Center for Neuroscience and Cell Biology, CIBB─Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.

Renata Silva (R)

Associate Laboratory i4HB─Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
UCIBIO─Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
ORCID: 0000-0001-9962-7548

Fernando Remião (F)

Associate Laboratory i4HB─Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
UCIBIO─Applied Molecular Biosciences Unit, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
ORCID: 0000-0003-1382-5119

Paulo J Oliveira (PJ)

CNC─Center for Neuroscience and Cell Biology, CIBB─Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, 3004-504 Coimbra, Portugal.
ORCID: 0000-0002-5201-9948

Eugenio Uriarte (E)

Departamento Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain.
Instituto de Ciencias Químicas Aplicadas, Universidad Autonoma de Chile, Av. Libertador Bernardo O'Higgins, 7500912 Santiago de Chile, Chile.

Fernanda Borges (F)

CIQUP-IMS─Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, 4169-007 Porto, Portugal.
ORCID: 0000-0003-1050-2402

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer III › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Modulating Cytotoxicity with Lego-like...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Tumeurs neuroectodermiques primitives périphériques › Neuroblastome › Modulating Cytotoxicity with Lego-like...