Mask R-CNN assisted 2.5D object detection pipeline of


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 01 2023
Historique:
received: 02 07 2022
accepted: 23 01 2023
entrez: 30 1 2023
pubmed: 31 1 2023
medline: 2 2 2023
Statut: epublish

Résumé

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is a molecular and functional imaging modality with better restaging accuracy over conventional imaging for detecting prostate cancer in men suspected of lymph node (LN) progression after definitive therapy. However, the availability of PSMA PET/CT is limited in both low-resource settings and for repeating imaging surveillance. In contrast, CT is widely available, cost-effective, and routinely performed as part of patient follow-up or radiotherapy workflow. Compared with the molecular activities, the morphological and texture changes of subclinical LNs in CT are subtle, making manual detection of positive LNs infeasible. Instead, we harness the power of artificial intelligence for automated LN detection on CT. We examined

Identifiants

pubmed: 36717727
doi: 10.1038/s41598-023-28669-y
pii: 10.1038/s41598-023-28669-y
pmc: PMC9886937
doi:

Substances chimiques

gallium 68 PSMA-11 0
Gallium Radioisotopes 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1696

Subventions

Organisme : NCI NIH HHS
ID : R01CA259008
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Di Xu (D)

Computer Science, University of California, Los Angeles, CA, 90035, USA.
Radiation Oncology, University of California, Los Angeles, CA, 90035, USA.

Martin Ma (M)

Radiation Oncology, University of California, Los Angeles, CA, 90035, USA.

Minsong Cao (M)

Radiation Oncology, University of California, Los Angeles, CA, 90035, USA.

Amar U Kishan (AU)

Radiation Oncology, University of California, Los Angeles, CA, 90035, USA.

Nicholas G Nickols (NG)

Department of Radiation Oncology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, 90035, USA.

Fabien Scalzo (F)

Computer Science, Pepperdine University, 24255 Pacific Coast Hwy, Los Angeles, CA, 90263, USA.

Ke Sheng (K)

Radiation Oncology, University of California, Los Angeles, CA, 90035, USA. ke.sheng@ucsf.edu.
Department of Radiation Oncology, University of California, San Francisco, CA, 94115, USA. ke.sheng@ucsf.edu.

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Classifications MeSH