Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis?
Angiogenesis
Large extracellular vesicles
Macrophages
Wound healing
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
30 01 2023
30 01 2023
Historique:
received:
10
11
2022
accepted:
17
01
2023
entrez:
31
1
2023
pubmed:
1
2
2023
medline:
2
2
2023
Statut:
epublish
Résumé
Large extracellular vesicles (L-EV) with a diameter between 1 and 10 µm are released by various cell types. L-EV contain and transport active molecules which are crucially involved in cell to cell communication. We have shown that secretory products of human regulatory macrophages (Mreg) bear pro-angiogenic potential in-vitro and our recent findings show that Mreg cultures also contain numerous large vesicular structures similar to L-EV with so far unknown characteristics and function. To characterize the nature of Mreg-derived L-EV (L-EV Mreg were differentiated using blood monocytes from healthy donors (N = 9) and L-EV Mreg and L-EV L-EV
Sections du résumé
BACKGROUND
Large extracellular vesicles (L-EV) with a diameter between 1 and 10 µm are released by various cell types. L-EV contain and transport active molecules which are crucially involved in cell to cell communication. We have shown that secretory products of human regulatory macrophages (Mreg) bear pro-angiogenic potential in-vitro and our recent findings show that Mreg cultures also contain numerous large vesicular structures similar to L-EV with so far unknown characteristics and function.
AIM OF THIS STUDY
To characterize the nature of Mreg-derived L-EV (L-EV
METHODS
Mreg were differentiated using blood monocytes from healthy donors (N = 9) and L-EV
RESULTS
Mreg and L-EV
CONCLUSION
L-EV
Identifiants
pubmed: 36717876
doi: 10.1186/s12967-023-03900-6
pii: 10.1186/s12967-023-03900-6
pmc: PMC9887800
doi:
Substances chimiques
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
61Informations de copyright
© 2023. The Author(s).
Références
Neuroscience. 2019 May 1;405:148-157
pubmed: 29660443
Cancer Med. 2018 May;7(5):2013-2020
pubmed: 29601673
Cancer Metastasis Rev. 2006 Mar;25(1):99-113
pubmed: 16680576
Clin Mol Hepatol. 2022 Oct;28(4):706-724
pubmed: 35232008
Cell Death Dis. 2020 Oct 28;11(10):924
pubmed: 33116121
Cancers (Basel). 2021 Oct 01;13(19):
pubmed: 34638439
Subcell Biochem. 2021;97:19-43
pubmed: 33779912
Sci Rep. 2020 Jul 14;10(1):11568
pubmed: 32665552
Nat Cell Biol. 2008 May;10(5):619-24
pubmed: 18425114
Front Cell Dev Biol. 2020 Dec 09;8:611039
pubmed: 33363175
Molecules. 2022 Feb 15;27(4):
pubmed: 35209095
Int J Nanomedicine. 2021 Aug 10;16:5395-5409
pubmed: 34408415
Semin Thromb Hemost. 2004 Feb;30(1):137-44
pubmed: 15034805
Int J Mol Sci. 2020 Sep 07;21(18):
pubmed: 32906787
J Extracell Vesicles. 2021 Dec;10(14):e12144
pubmed: 34919343
J Transl Med. 2022 Jun 7;20(1):258
pubmed: 35672774
J Transl Med. 2021 Mar 6;19(1):99
pubmed: 33676540
J Extracell Vesicles. 2021 Dec;10(14):e12182
pubmed: 34953156
Front Immunol. 2018 Dec 13;9:2723
pubmed: 30619239
Biomedicines. 2021 Jun 23;9(7):
pubmed: 34201592
Adv Sci (Weinh). 2019 Aug 27;6(20):1900513
pubmed: 31637157
Physiology (Bethesda). 2019 May 1;34(3):169-177
pubmed: 30968753
Joint Bone Spine. 2015 Jan;82(1):8-12
pubmed: 25241337
Oral Dis. 2010 Jan;16(1):34-8
pubmed: 19627513
Kidney Int. 2014 Aug;86(2):433-44
pubmed: 24352158
Microvasc Res. 2007 Sep-Nov;74(2-3):172-83
pubmed: 17631914
J Transl Med. 2022 May 14;20(1):224
pubmed: 35568952
Biochem Biophys Res Commun. 2020 Mar 12;523(3):685-691
pubmed: 31948757
iScience. 2020 Jun 26;23(6):101135
pubmed: 32442747
J Neurooncol. 2013 May;113(1):1-11
pubmed: 23456661
J Extracell Vesicles. 2018 Nov 30;7(1):1548234
pubmed: 30533205
Cytokine Growth Factor Rev. 2020 Feb;51:69-74
pubmed: 31937439
J Immunol. 2007 Aug 1;179(3):1969-78
pubmed: 17641064
Exp Cell Res. 2020 Sep 15;394(2):112146
pubmed: 32561287
Curr Pharm Des. 2003;9(19):1545-64
pubmed: 12871067
Sci Rep. 2021 Oct 4;11(1):19616
pubmed: 34608184
Cancer Res. 2009 Jul 1;69(13):5601-9
pubmed: 19549916
Nat Protoc. 2007;2(3):481-5
pubmed: 17406610
Immunohorizons. 2021 Aug 17;5(8):647-658
pubmed: 34404719
Stem Cells Int. 2019 Jun 25;2019:3725863
pubmed: 31341483
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Mol Med. 2011 Sep-Oct;17(9-10):1045-55
pubmed: 21670847
Clin Sci (Lond). 2015 Jun;128(11):805-23
pubmed: 25881671
J Transl Med. 2020 May 15;18(1):202
pubmed: 32414386
Front Immunol. 2018 Jun 28;9:1486
pubmed: 30002658
Acta Biochim Biophys Sin (Shanghai). 2016 May;48(5):399-410
pubmed: 26705141
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Cell Prolif. 2020 Feb;53(2):e12753
pubmed: 31957193
Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2514-23
pubmed: 17872453
Cell Mol Neurobiol. 2016 Apr;36(3):301-12
pubmed: 27053351
Front Immunol. 2018 Aug 06;9:1789
pubmed: 30131806
Cancers (Basel). 2020 Dec 09;12(12):
pubmed: 33317058