Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant

Applied microbiology Clinical microbiology Microbiology parasite Multi-drug resistant organisms Natural product chemistry

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
17 Feb 2023
Historique:
received: 23 11 2022
revised: 23 12 2022
accepted: 05 01 2023
entrez: 31 1 2023
pubmed: 1 2 2023
medline: 1 2 2023
Statut: epublish

Résumé

Malaria eradication requires the development of new drugs to combat drug-resistant parasites. We identified bisbenzylisoquinoline alkaloids isolated from

Identifiants

pubmed: 36718363
doi: 10.1016/j.isci.2023.105940
pii: S2589-0042(23)00017-2
pmc: PMC9883252
doi:

Types de publication

Journal Article

Langues

eng

Pagination

105940

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

Authors F.N., H.H., L.H., A.S. and P.B.A. declare a patent entitled Trilobine derivatives and use thereof in the treatment of malaria reference WO2021/224491 A1 (11/11/2021).

Références

J Nat Prod. 1999 Jan;62(1):59-66
pubmed: 9917283
J Ethnopharmacol. 2005 Oct 31;102(1):89-94
pubmed: 15996841
Annu Rev Biochem. 1999;68:913-63
pubmed: 10872469
Biochem J. 2015 Aug 15;470(1):115-29
pubmed: 26251451
Antimicrob Agents Chemother. 2015 Feb;59(2):950-9
pubmed: 25421480
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612
pubmed: 33237311
Trends Parasitol. 2020 Sep;36(9):735-744
pubmed: 32586776
Medicines (Basel). 2020 Nov 10;7(11):
pubmed: 33182572
Malar J. 2011 Mar 15;10 Suppl 1:S3
pubmed: 21411014
Biochem Biophys Res Commun. 1989 Dec 15;165(2):758-65
pubmed: 2688645
Antimicrob Agents Chemother. 1994 Jan;38(1):96-103
pubmed: 8141587
Nat Protoc. 2015 Dec;10(12):2027-53
pubmed: 26584444
Nat Protoc. 2016 May;11(5):976-92
pubmed: 27123949
Parasitol Int. 2009 Dec;58(4):481-5
pubmed: 19751846
Chem Biol. 2012 Jan 27;19(1):116-29
pubmed: 22284359
PLoS One. 2012;7(2):e30949
pubmed: 22383983
ACS Cent Sci. 2020 Jan 22;6(1):16-21
pubmed: 31989022
Cold Spring Harb Perspect Med. 2017 Jul 5;7(7):
pubmed: 28289248
Ann Trop Med Parasitol. 1975 Jun;69(2):155-71
pubmed: 1098584
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12020-4
pubmed: 8265664
Mol Microbiol. 2006 Feb;59(4):1175-84
pubmed: 16430692
J Nat Prod. 1997 Mar;60(3):258-60
pubmed: 9157192
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Nat Rev Microbiol. 2015 Sep;13(9):573-87
pubmed: 26272409
Antimicrob Agents Chemother. 1996 Jun;40(6):1476-81
pubmed: 8726022
J Proteome Res. 2011 Apr 1;10(4):1794-805
pubmed: 21254760
ACS Chem Biol. 2020 Apr 17;15(4):952-961
pubmed: 32191434
J Nat Prod. 1993 Jan;56(1):30-8
pubmed: 8450319
PLoS One. 2015 Dec 30;10(12):e0146021
pubmed: 26717316
Science. 2018 May 4;360(6388):
pubmed: 29724925
Nat Microbiol. 2017 Mar 13;2:17031
pubmed: 28288098
Lancet Infect Dis. 2013 Dec;13(12):1043-9
pubmed: 24035558
Cell Host Microbe. 2013 Jul 17;14(1):104-15
pubmed: 23870318
ACS Infect Dis. 2018 Apr 13;4(4):523-530
pubmed: 29377668
Commun Integr Biol. 2009 May;2(3):245-60
pubmed: 19641745
Science. 1976 Aug 20;193(4254):673-5
pubmed: 781840
Malar J. 2016 Feb 24;15:116
pubmed: 26911594
Trans R Soc Trop Med Hyg. 1982;76(6):812-8
pubmed: 6761910

Auteurs

Flore Nardella (F)

Biology of Host-Parasite Interaction, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris-Cité, CNRS EMR 9195, INSERM Unit U1201, 25-28 Rue du Dr Roux, 75015 Paris, France.

Irina Dobrescu (I)

Biology of Host-Parasite Interaction, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris-Cité, CNRS EMR 9195, INSERM Unit U1201, 25-28 Rue du Dr Roux, 75015 Paris, France.

Haitham Hassan (H)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Fabien Rodrigues (F)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Sabine Thiberge (S)

Biology of Host-Parasite Interaction, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris-Cité, CNRS EMR 9195, INSERM Unit U1201, 25-28 Rue du Dr Roux, 75015 Paris, France.
Center for Production and Infection of Anopheles (CEPIA), Center for Animal Resources and Research, Institut Pasteur, 75015 Paris, France.

Liliana Mancio-Silva (L)

Biology of Host-Parasite Interaction, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris-Cité, CNRS EMR 9195, INSERM Unit U1201, 25-28 Rue du Dr Roux, 75015 Paris, France.

Ambre Tafit (A)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Corinne Jallet (C)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Véronique Cadet-Daniel (V)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Stéphane Goussin (S)

Center for Production and Infection of Anopheles (CEPIA), Center for Animal Resources and Research, Institut Pasteur, 75015 Paris, France.

Audrey Lorthiois (A)

Center for Production and Infection of Anopheles (CEPIA), Center for Animal Resources and Research, Institut Pasteur, 75015 Paris, France.

Yoann Menon (Y)

USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

Nicolas Molinier (N)

USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

Dany Pechalrieu (D)

USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

Christophe Long (C)

USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

François Sautel (F)

USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

Mariette Matondo (M)

Proteomics Platform, Mass Spectrometry for Biology Unit, Institut Pasteur, Université de Paris-Cité, CNRS USR 2000, 28 rue du Dr Roux, 75015 Paris, France.

Magalie Duchateau (M)

Proteomics Platform, Mass Spectrometry for Biology Unit, Institut Pasteur, Université de Paris-Cité, CNRS USR 2000, 28 rue du Dr Roux, 75015 Paris, France.

Guillaume Médard (G)

Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, 85354 Freising, Germany.

Benoit Witkowski (B)

Malaria Molecular Epidemiology Unit, Pasteur Institute in Cambodia, Phnom Penh 12201, Cambodia.

Artur Scherf (A)

Biology of Host-Parasite Interaction, Department of Parasites and Insect Vectors, Institut Pasteur, Université de Paris-Cité, CNRS EMR 9195, INSERM Unit U1201, 25-28 Rue du Dr Roux, 75015 Paris, France.

Ludovic Halby (L)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.

Paola B Arimondo (PB)

Epigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, Université de Paris-Cité, UMR n°3523, CNRS, 28 Rue du Dr Roux, 75015 Paris, France.
USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 Avenue Hubert Curien, 31035 Toulouse Cedex 01, France.

Classifications MeSH