Next-generation antigen-presenting cell immune therapeutics for gliomas.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
01 02 2023
01 02 2023
Historique:
pubmed:
1
2
2023
medline:
3
2
2023
entrez:
31
1
2023
Statut:
epublish
Résumé
Antigen presentation machinery and professional antigen-presenting cells (APCs) are fundamental for an efficacious immune response against cancers, especially in the context of T cell-centric immunotherapy. Dendritic cells (DCs), the gold standard APCs, play a crucial role in initiating and maintaining a productive antigen-specific adaptive immunity. In recent decades, ex vivo-differentiated DCs from circulating CD14+ monocytes have become the reference for APC-based immunotherapy. DCs loaded with tumor-associated antigens, synthetic peptides, or RNA activate T cells with antitumor properties. This strategy has paved the way for the development of alternative antigen-presenting vaccination strategies, such as monocytes, B cells, and artificial APCs, that have shown effective therapeutic outcomes in preclinical cancer models. The search for alternative APC platforms was initiated by the overall limited clinical impact of DC vaccines, especially in indications such as gliomas, a primary brain tumor known for resistance to any immune intervention. In this Review, we navigate the APC immune therapeutics' past, present, and future in the context of primary brain tumors.
Identifiants
pubmed: 36719372
pii: 163449
doi: 10.1172/JCI163449
pmc: PMC9888388
doi:
pii:
Substances chimiques
Cancer Vaccines
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R37 CA258426
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197725
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA221747
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS115955
Pays : United States
Références
Immunity. 2013 Jul 25;39(1):38-48
pubmed: 23890062
Cancer Gene Ther. 2021 Feb;28(1-2):5-17
pubmed: 32457487
J Neuroimmunol. 2000 Jun 26;105(2):115-9
pubmed: 10742552
Cancer Cell. 2008 Oct 7;14(4):299-311
pubmed: 18835032
J Immunother Cancer. 2021 Jun;9(6):
pubmed: 34083417
J Immunol. 2012 Jul 1;189(1):444-53
pubmed: 22664874
Neurosci Lett. 2017 Apr 3;645:106-112
pubmed: 28259657
Nat Med. 2000 Oct;6(10):1160-6
pubmed: 11017149
Oncoimmunology. 2018 Jun 11;7(8):e1465165
pubmed: 30221062
J Clin Invest. 2014 Dec;124(12):5466-80
pubmed: 25384214
Nat Rev Immunol. 2020 Jan;20(1):7-24
pubmed: 31467405
Nat Rev Immunol. 2016 Mar;16(3):149-63
pubmed: 26875830
Cancer Res. 2004 Feb 1;64(3):920-7
pubmed: 14871821
J Immunol. 2016 Apr 15;196(8):3385-97
pubmed: 26983789
Nat Rev Immunol. 2020 May;20(5):294-307
pubmed: 31988391
Front Immunol. 2022 Feb 28;13:844866
pubmed: 35296095
Nat Commun. 2019 Sep 13;10(1):4186
pubmed: 31519915
Scand J Immunol. 2020 Feb;91(2):e12830
pubmed: 31823416
Semin Cancer Biol. 2015 Dec;35 Suppl:S185-S198
pubmed: 25818339
Hum Pathol. 2016 Aug;54:157-64
pubmed: 27107457
Neuro Oncol. 2010 Nov;12(11):1113-25
pubmed: 20667896
J Neuroimmune Pharmacol. 2013 Sep;8(4):840-56
pubmed: 23695293
Cancer Immunol Res. 2017 Oct;5(10):898-907
pubmed: 28848053
J Neuroimmunol. 2013 Nov 15;264(1-2):71-83
pubmed: 24045166
Nat Rev Immunol. 2009 Jan;9(1):15-27
pubmed: 19079135
Clin Cancer Res. 2018 Dec 15;24(24):6125-6135
pubmed: 30049748
Bone Marrow Transplant. 2004 Jan;33(1):53-60
pubmed: 14578928
Int J Biochem Cell Biol. 2014 Dec;57:63-8
pubmed: 25450457
Acta Neuropathol. 2012 Nov;124(5):599-614
pubmed: 22825593
Nanomedicine (Lond). 2013 Jul;8(7):1173-89
pubmed: 23837856
Nat Commun. 2018 Feb 12;9(1):633
pubmed: 29434238
Front Immunol. 2021 Aug 30;12:726421
pubmed: 34526998
Mol Ther. 2010 Feb;18(2):413-20
pubmed: 19773745
Nature. 2020 Jan;577(7791):549-555
pubmed: 31942075
Haematologica. 2008 Oct;93(10):1523-34
pubmed: 18728033
Blood. 2005 Jul 1;106(1):144-9
pubmed: 15731181
Exp Cell Res. 2017 Nov 15;360(2):66-73
pubmed: 28782555
Nat Med. 2001 Mar;7(3):297-303
pubmed: 11231627
Nature. 2020 Jan;577(7791):556-560
pubmed: 31942077
Eur J Pharm Sci. 2018 Mar 1;114:228-237
pubmed: 29277666
J Comp Neurol. 1999 Mar 22;405(4):553-62
pubmed: 10098945
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23714-23723
pubmed: 31712430
Clin Cancer Res. 2019 Oct 1;25(19):5799-5807
pubmed: 31320597
J Clin Invest. 1997 Dec 1;100(11):2757-65
pubmed: 9389740
Nat Rev Cancer. 2019 Oct;19(10):568-586
pubmed: 31462760
Nano Lett. 2021 Mar 10;21(5):2094-2103
pubmed: 33622034
Sci Immunol. 2020 Jun 5;5(48):
pubmed: 32503876
Oncoimmunology. 2015 Jun 17;4(9):e1038684
pubmed: 26405608
Cancer Res. 2008 Jul 15;68(14):5955-64
pubmed: 18632651
Nat Med. 1998 May;4(5):594-600
pubmed: 9585234
Clin Cancer Res. 2005 Aug 1;11(15):5515-25
pubmed: 16061868
J Clin Invest. 1999 Jul;104(2):173-80
pubmed: 10411546
Neoplasia. 2011 Oct;13(10):947-60
pubmed: 22028620
Cancer Cell. 2016 Jul 11;30(1):120-135
pubmed: 27374224
PLoS One. 2017 Jun 21;12(6):e0179793
pubmed: 28636654
Cancer Immunol Immunother. 2009 Feb;58(2):209-20
pubmed: 18563409
Immunity. 2006 Jul;25(1):153-62
pubmed: 16860764
Trends Immunol. 2015 Apr;36(4):229-39
pubmed: 25770924
Cancer Res. 2016 Oct 1;76(19):5597-5601
pubmed: 27634765
Nat Med. 2006 Jun;12(6):693-8
pubmed: 16680149
Cancer Immunol Res. 2021 Sep;9(9):1098-1108
pubmed: 34155067
Breast Cancer. 2019 Mar;26(2):180-189
pubmed: 30244409
Cell. 2020 Mar 19;180(6):1081-1097.e24
pubmed: 32142650
Clin Cancer Res. 2007 Dec 15;13(24):7329-34
pubmed: 18094414
Gynecol Oncol. 2016 Oct;143(1):120-127
pubmed: 27470997
Nature. 2015 Mar 19;519(7543):366-9
pubmed: 25762141
Glia. 2005 Sep;51(4):279-85
pubmed: 15818597
Cancers (Basel). 2021 Jan 04;13(1):
pubmed: 33406696
J Clin Invest. 2010 May;120(5):1368-79
pubmed: 20440079
Neuropathol Appl Neurobiol. 1998 Aug;24(4):293-301
pubmed: 9775395
Diabetes. 2012 Nov;61(11):2893-905
pubmed: 22829452
Clin Cancer Res. 2006 Oct 1;12(19):5834-40
pubmed: 17020991
Br J Cancer. 2004 Nov 1;91(9):1656-62
pubmed: 15477864
Clin Cancer Res. 2005 Jun 1;11(11):4160-7
pubmed: 15930352
Sci Rep. 2019 Dec 27;9(1):19997
pubmed: 31882709
J Neuroimmune Pharmacol. 2013 Mar;8(1):145-62
pubmed: 23114889
Blood. 2014 Aug 28;124(9):1450-9
pubmed: 25037628
Cell Res. 2020 Mar;30(3):229-243
pubmed: 32094452
Cancer Immunol Immunother. 2013 Jan;62(1):125-35
pubmed: 22847020
Cell. 2020 Jun 25;181(7):1643-1660.e17
pubmed: 32470396
Transfus Med Hemother. 2019 Feb;46(1):36-46
pubmed: 31244580
Cancer Res. 2016 Oct 1;76(19):5671-5682
pubmed: 27530322
Immunity. 2006 Feb;24(2):191-201
pubmed: 16473831
Breast Cancer Res Treat. 2012 Apr;132(2):545-53
pubmed: 21671016
Front Immunol. 2018 May 30;9:1209
pubmed: 29899747
Immunity. 2018 Apr 17;48(4):812-830.e14
pubmed: 29628290
Oncotarget. 2016 Dec 6;7(49):80521-80542
pubmed: 27602954
J Exp Med. 2021 Jan 4;218(1):
pubmed: 32991668
Sci Adv. 2021 Oct;7(40):eabh3243
pubmed: 34586841
Cancer Sci. 2007 Aug;98(8):1226-33
pubmed: 17517052
Neuro Oncol. 2012 May;14(5):584-95
pubmed: 22406925
Neuropathol Appl Neurobiol. 1999 Apr;25(2):113-22
pubmed: 10215999
Cancer Immunol Immunother. 2020 Jan;69(1):81-94
pubmed: 31844909
Clin Cancer Res. 2012 Nov 15;18(22):6110-21
pubmed: 22932670
JCI Insight. 2019 Aug 13;5:
pubmed: 31408436
Cancer Sci. 2013 Feb;104(2):200-5
pubmed: 23106822
PLoS One. 2018 Jul 5;13(7):e0199414
pubmed: 29975720
Blood. 2004 Jul 1;104(1):224-6
pubmed: 15031203
Cell. 2019 Jul 11;178(2):346-360.e24
pubmed: 31257026
Cell. 2019 Aug 8;178(4):835-849.e21
pubmed: 31327527
Gene Ther. 2014 Jan;21(1):106-14
pubmed: 24225639
Nature. 2020 Jan;577(7791):561-565
pubmed: 31942071
PLoS One. 2018 Jul 5;13(7):e0199034
pubmed: 29975708
J Neuroimmunol. 2000 Feb 1;103(1):16-25
pubmed: 10674985
JAMA Oncol. 2023 Jan 1;9(1):112-121
pubmed: 36394838
Nat Rev Immunol. 2011 Jul 25;11(8):519-31
pubmed: 21785456
Eur J Immunol. 1993 Oct;23(10):2631-41
pubmed: 8405064
Immunohorizons. 2021 Jun 25;5(6):500-511
pubmed: 34172533
Nat Commun. 2022 Feb 17;13(1):925
pubmed: 35177622
J Immunother. 2011 May;34(4):382-9
pubmed: 21499132
J Immunother Cancer. 2020 Aug;8(2):
pubmed: 32859742
Sci Rep. 2019 Sep 11;9(1):13083
pubmed: 31511630
Nat Med. 1997 Jun;3(6):682-5
pubmed: 9176498
J Clin Invest. 2020 Feb 3;130(2):774-788
pubmed: 31661470
Cancer J. 2010 Jul-Aug;16(4):374-81
pubmed: 20693850
Int Immunol. 2002 Apr;14(4):411-9
pubmed: 11934877
Neurosurg Focus. 2000 Dec 15;9(6):e8
pubmed: 16817691
Cancer Cell. 2021 Jun 14;39(6):779-792.e11
pubmed: 34087162
Eur J Cancer. 2008 Feb;44(3):383-90
pubmed: 18060766
Curr Opin Immunol. 2001 Jun;13(3):291-8
pubmed: 11406360
Gut. 2017 Feb;66(2):342-351
pubmed: 26669617
Lab Invest. 2005 Mar;85(3):328-41
pubmed: 15716863
J Exp Med. 1994 Jul 1;180(1):157-63
pubmed: 7516405
Sci Adv. 2021 Feb 17;7(8):
pubmed: 33597238
Am J Pathol. 2012 Nov;181(5):1749-61
pubmed: 22982440
Clin Cancer Res. 2007 Mar 15;13(6):1857-67
pubmed: 17363542
JAMA. 2017 Dec 19;318(23):2306-2316
pubmed: 29260225
Transl Res. 2016 Feb;168:74-95
pubmed: 26297944
Cancer Immunol Immunother. 2013 Sep;62(9):1499-509
pubmed: 23817721
Cancer Immunol Res. 2019 Dec;7(12):1928-1943
pubmed: 31530559
Cancer Immunol Res. 2017 Sep;5(9):730-743
pubmed: 28778961
J Immunother Cancer. 2019 Sep 4;7(1):238
pubmed: 31484548
Nat Med. 2015 Feb;21(2):117-9
pubmed: 25654601
Am J Respir Crit Care Med. 2014 Apr 1;189(7):832-44
pubmed: 24484236
Clin Immunol. 2018 Feb;187:37-45
pubmed: 29031828
Eur J Cancer. 2016 Nov;68:134-147
pubmed: 27755997
Nat Biotechnol. 2004 Apr;22(4):403-10
pubmed: 15060556
Neuroscience. 1996 Sep;74(2):599-608
pubmed: 8865208
Int J Cancer. 2008 Nov 15;123(10):2354-61
pubmed: 18729197
Blood. 2006 Feb 15;107(4):1528-36
pubmed: 16239433
Br J Cancer. 2013 Nov 12;109(10):2665-74
pubmed: 24136146
Nature. 2011 Mar 31;471(7340):629-32
pubmed: 21455179
Blood. 2003 Sep 15;102(6):2004-13
pubmed: 12763934
J Immunol. 2009 Mar 15;182(6):3650-9
pubmed: 19265143
J Neurosurg. 2011 Aug;115(2):248-55
pubmed: 21568657
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8670-5
pubmed: 15163797
Acta Neuropathol. 1990;80(3):287-94
pubmed: 2399810
J Neurosurg. 1999 Jun;90(6):1115-24
pubmed: 10350260
Nat Med. 1996 Jan;2(1):52-8
pubmed: 8564842
Clin Cancer Res. 2012 Jun 15;18(12):3281-92
pubmed: 22553348
Trends Cell Biol. 2020 Sep;30(9):695-704
pubmed: 32624246