SARS-CoV-2 and omicron variant detection with a high selectivity, sensitivity, and low-cost silicon bio-nanosensor.
SARS‐CoV‐2
biosensor
omicron
optical sensing
silicon nanowires
Journal
Nano select : open access
ISSN: 2688-4011
Titre abrégé: Nano Sel
Pays: Germany
ID NLM: 9918249608306676
Informations de publication
Date de publication:
29 Dec 2022
29 Dec 2022
Historique:
received:
28
08
2022
revised:
25
10
2022
accepted:
13
11
2022
entrez:
1
2
2023
pubmed:
2
2
2023
medline:
2
2
2023
Statut:
aheadofprint
Résumé
The recent SARS-CoV-2 pandemic has highlighted the urgent need for novel point-of-care devices to be promptly used for a rapid and reliable large screening analysis of several biomarkers like genetic sequences and antibodies. Currently, one of the main limitations of rapid tests is the high percentage of false negatives in the presence of variants and, in particular for the Omicron one. We demonstrate in this work the detection of SARS-CoV-2 and the Omicron variant with a cost-effective silicon nanosensor enabling high sensitivity, selectivity, and fast response. We have shown that a silicon (Si) nanowires (NW) platform detects both Sars-CoV-2 and its Omicron variant with a limit of detection (LoD) of four effective copies (cps), without any amplification of the genome, and with high selectivity. This ultrasensitive detection of 4 cps allows to obtain an extremely early diagnosis paving the way for efficient and widespread tracking. The sensor is made with industrially compatible techniques, which in perspective may allow easy and cost-effective industrialization.
Identifiants
pubmed: 36721465
doi: 10.1002/nano.202200188
pii: NANO202200188
pmc: PMC9880655
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2022 The Authors. Nano Select published by Wiley‐VCH GmbH.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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