SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3.

Adaptor Proteins, Signal Transducing / genetics COVID-19 / virology Interferon Type I / metabolism Intracellular Signaling Peptides and Proteins / metabolism Methyltransferases / metabolism RNA-Binding Proteins / genetics SARS-CoV-2 / genetics Viral Nonstructural Proteins / metabolism Animals Cricetinae
2'-O-methyltransferase IFIT1 IFIT3 NSP16 SARS-CoV-2 antiviral agents coronavirus interferon-stimulated gene

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
28 02 2023
Historique:
pubmed: 2 2 2023
medline: 3 3 2023
entrez: 1 2 2023
Statut: ppublish

Résumé

Understanding the molecular basis of innate immune evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important consideration for designing the next wave of therapeutics. Here, we investigate the role of the nonstructural protein 16 (NSP16) of SARS-CoV-2 in infection and pathogenesis. NSP16, a ribonucleoside 2'-

Identifiants

DOI: 10.1128/jvi.01532-22 PMID: 36722972 PMC: PMC9973020
pubmed: 36722972
doi: 10.1128/jvi.01532-22
pmc: PMC9973020
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Interferon Type I 0
Intracellular Signaling Peptides and Proteins 0
Methyltransferases EC 2.1.1.-
RNA-Binding Proteins 0
Viral Nonstructural Proteins 0
NSP16 protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0153222

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI145400
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133633
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI171413
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153602
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007526
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States

Commentaires et corrections

Type : UpdateOf

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Auteurs

Craig Schindewolf (C)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.

Kumari Lokugamage (K)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

Michelle N Vu (MN)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

Bryan A Johnson (BA)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.

Dionna Scharton (D)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA.

Jessica A Plante (JA)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA.

Birte Kalveram (B)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.

Patricia A Crocquet-Valdes (PA)

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Stephanea Sotcheff (S)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.

Elizabeth Jaworski (E)

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.

Rojelio E Alvarado (RE)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, USA.

Kari Debbink (K)

Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA.

Matthew D Daugherty (MD)

Department of Molecular Biology, University of California, San Diego, California, USA.

Scott C Weaver (SC)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA.

Andrew L Routh (AL)

Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
ORCID: 0000-0002-2874-5990

David H Walker (DH)

Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch, Galveston, Texas, USA.

Kenneth S Plante (KS)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA.

Vineet D Menachery (VD)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA.
World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA.
ORCID: 0000-0001-8803-7606

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Eucaryotes › Animaux › SARS-CoV-2 Uses Nonstructural Protein 16 To...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › SARS-CoV-2 Uses Nonstructural Protein 16 To...