Total synthesis of (-)-domoic acid, a potent ionotropic glutamate receptor agonist and the key compound in oceanic harmful algal blooms.

Harmful Algal Bloom Receptors, Ionotropic Glutamate Kainic Acid

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
22 02 2023
Historique:
pubmed: 2 2 2023
medline: 25 2 2023
entrez: 1 2 2023
Statut: epublish

Résumé

The stereo-controlled total synthesis of (-)-domoic acid is described. The critical construction of the C1'-C2'

Identifiants

DOI: 10.1039/d2ob02325c PMID: 36723220
pubmed: 36723220
doi: 10.1039/d2ob02325c
doi:

Substances chimiques

domoic acid M02525818H
Receptors, Ionotropic Glutamate 0
Kainic Acid SIV03811UC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1653-1656

Auteurs

Shigeru Nishizawa (S)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Hitoshi Ouchi (H)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.
ORCID: 0000-0001-6519-0990

Hiroto Suzuki (H)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Takuma Ohnishi (T)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Shingo Sasaki (S)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Yu Oyagi (Y)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Masaki Kanakogi (M)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Yoshitaka Matsumura (Y)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Shunsuke Nakagawa (S)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Tomohiro Asakawa (T)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Masahiro Egi (M)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

Makoto Inai (M)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.
ORCID: 0000-0001-7074-0520

Fumihiko Yoshimura (F)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.
ORCID: 0000-0002-1187-6062

Ryo Takita (R)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.
ORCID: 0000-0003-4104-9890

Toshiyuki Kan (T)

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. ouchih@u-shizuoka-ken.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Eutrophisation › Prolifération d'algues nuisibles › Total synthesis of (-)-domoic acid, a potent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Total synthesis of (-)-domoic acid, a potent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Acide kaïnique › Total synthesis of (-)-domoic acid, a potent...