Anti-Atherosclerotic Action of a New Stimulator of Soluble Guanylate Cyclase in an Experiment.
endothelial dysfunction
experimental model of atherosclerosis
indolinone derivative
soluble guanylate cyclase stimulator
xanthoma cells
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
11
07
2022
pubmed:
2
2
2023
medline:
14
2
2023
entrez:
1
2
2023
Statut:
ppublish
Résumé
We studied the effect of an indolinone derivative GRS on the development of experimental atherosclerosis in C57BL/6 mice. Atherosclerosis was modeled by intraperitoneal administration of endothelial lipoprotein lipase inhibitor Kolliphor P 407 micro Geismar over 5 months. GRS was administered orally in a dose of 10 mg/kg once a day throughout the experiment. In 5 months, the levels of total cholesterol, LDL, and triglycerides in blood serum, as well as histological composition of the ascending aorta were studied. In mice with experimental atherosclerosis, we observed pronounced dyslipidemia with an increase in serum cholesterol, LDL, and triglycerides and accumulation of xanthoma cells in the aorta wall. Repeat administration of GRS did not eliminate dyslipidemia, but prevented an increase in the number of xanthoma cells in the aorta wall (p<0.05). The stimulator of soluble guanylate cyclase GRS did not exhibit hypolipidemic activity, but restored impaired endothelial function in the atherosclerosis model and prevented atherosclerotic damage to blood vessels and vascular wall remodeling.
Identifiants
pubmed: 36723753
doi: 10.1007/s10517-023-05703-7
pii: 10.1007/s10517-023-05703-7
doi:
Substances chimiques
Soluble Guanylyl Cyclase
EC 4.6.1.2
Cholesterol, LDL
0
Triglycerides
0
Guanylate Cyclase
EC 4.6.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-336Informations de copyright
© 2023. Springer Science+Business Media, LLC, part of Springer Nature.
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