Alloantigen Copy Number as a Critical Factor in RBC Alloimmunization.
Alloantibody
Alloimmunization
RBC Transfusion
Red Blood Cell
Journal
Transfusion medicine reviews
ISSN: 1532-9496
Titre abrégé: Transfus Med Rev
Pays: United States
ID NLM: 8709027
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
22
11
2022
revised:
19
12
2022
accepted:
20
12
2022
pmc-release:
01
01
2024
pubmed:
2
2
2023
medline:
21
3
2023
entrez:
1
2
2023
Statut:
ppublish
Résumé
RBC alloimmunization remains a significant barrier to ongoing transfusion therapy leading to morbidity, and in extreme cases mortality, due to delayed or insufficient units of compatible RBCs. In addition, the monitoring and characterization of alloantibodies, often with multiple specificities in a single patient, consumes substantial health care resources. Extended phenotypic matching has mitigated, but not eliminated, RBC alloimmunization and is only logistically available for specialized populations. Thus, RBC alloimmunization remains a substantial problem. In recent decades it has become clear that mechanisms of RBC alloimmunization are distinct from other antigens and lack of mechanistic understanding likely contributes to the fact that there are no approved interventions to prevent RBC alloimmunization from transfusion. The combination of human studies and murine modeling have identified several key factors in RBC alloimmunization. In both humans and mice, immunogenicity is a function of alloantigen copy number on RBCs. Murine studies have further shown that copy number not only changes rates of immunization but the mechanisms of antibody formation. This review summarizes the current understanding of quantitative and qualitative effects of alloantigen copy number on RBC alloimmunization.
Identifiants
pubmed: 36725483
pii: S0887-7963(22)00067-0
doi: 10.1016/j.tmrv.2022.12.009
pmc: PMC10023450
mid: NIHMS1870065
pii:
doi:
Substances chimiques
Isoantigens
0
Isoantibodies
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-26Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL132819
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL150626
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
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