Slow TCA flux and ATP production in primary solid tumours but not metastases.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2023
Historique:
received: 03 11 2021
accepted: 14 12 2022
pubmed: 2 2 2023
medline: 11 2 2023
entrez: 1 2 2023
Statut: ppublish

Résumé

Tissues derive ATP from two pathways-glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain. Most energy in mammals is produced via TCA metabolism

Identifiants

pubmed: 36725930
doi: 10.1038/s41586-022-05661-6
pii: 10.1038/s41586-022-05661-6
pmc: PMC10288502
mid: NIHMS1901201
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE
Hras protein, mouse EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

349-357

Subventions

Organisme : NIDDK NIH HHS
ID : F32 DK127843
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237347
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA242379
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM128813
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA273517
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211437
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236936
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK113643
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007388
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163591
Pays : United States

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Caroline R Bartman (CR)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Daniel R Weilandt (DR)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Yihui Shen (Y)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.

Won Dong Lee (WD)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.

Yujiao Han (Y)

Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Tara TeSlaa (T)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.

Connor S R Jankowski (CSR)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Laith Samarah (L)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Noel R Park (NR)

Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Victoria da Silva-Diz (V)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Maya Aleksandrova (M)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Yetis Gultekin (Y)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Boston, MA, USA.
Department of Biology, Massachusetts Institute of Technology, Boston, MA, USA.

Argit Marishta (A)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Lin Wang (L)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Lifeng Yang (L)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.

Asael Roichman (A)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Vrushank Bhatt (V)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Taijin Lan (T)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Zhixian Hu (Z)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Xi Xing (X)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Wenyun Lu (W)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.

Shawn Davidson (S)

Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.

Martin Wühr (M)

Department of Chemistry, Princeton University, Princeton, NJ, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Matthew G Vander Heiden (MG)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Boston, MA, USA.
Department of Biology, Massachusetts Institute of Technology, Boston, MA, USA.

Daniel Herranz (D)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Jessie Yanxiang Guo (JY)

Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA.

Yibin Kang (Y)

Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Joshua D Rabinowitz (JD)

Department of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.

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