Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle.
RNA interference
controlled release
fibrin
lipopolyplex
Journal
Regenerative biomaterials
ISSN: 2056-3418
Titre abrégé: Regen Biomater
Pays: England
ID NLM: 101652150
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
08
2022
revised:
02
11
2022
accepted:
24
11
2022
entrez:
2
2
2023
pubmed:
3
2
2023
medline:
3
2
2023
Statut:
epublish
Résumé
RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual tissues. Injectable hydrogels are one potentially simple and direct route towards overcoming these barriers. Here we report on the utility of a combination of a mildly modified form of the clinically utilised fibrin hydrogel with Invivofectamine
Identifiants
pubmed: 36726610
doi: 10.1093/rb/rbac101
pii: rbac101
pmc: PMC9887344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
rbac101Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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