Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.

High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12-1.62] mmol/L vs. HDL-C = 1.55 [1.22-1.97] mmol/L,

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Copyright © 2023 Tanaka, Tymowski, Tran-Dinh, Meilhac, Lortat-Jacob, Zappella, Jean-Baptiste, Robert, Goletto, Godet, Castier, Mal, Mordant, Atchade, Messika, Montravers and the Bichat Lung Transplant Group.

Déclaration de conflit d'intérêts

CG reports having received grant support from Ohre Pharma, Pfizer, MSD, SOS Oxygène, ISIS Medical, Vivisol, Elivie and AstraZeneca, speaker fees, travel support from Pfizer, MSD and speaker fees for board memberships from SOS Oxygène and Pulmatrix. JM received congress reimbursement fees from Biotest and CSL Behring, Fingers Xed. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.