A prospective 18 F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 05 2023
01 05 2023
Historique:
medline:
6
4
2023
pubmed:
3
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
HIV affects 36 million people globally with prevalence decreasing due to antiretroviral therapy (ART) and social awareness; transmission occurs during substance use. Cocaine usage independently affects brain activity and may result in reduced ART adherence. This study evaluates brain glucose metabolism measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in cocaine users with HIV infection. Sixty-three participants were categorized into groups: 36 HIV infected (HIV+) and 27 non-HIV infected (HIV-) individuals. Each group was further split into cocaine users (CO+) and non-cocaine users (CO-). Of the HIV+, half were cocaine users and half were not. Of the HIV-, 14 were cocaine users and 13 were not. 18 F-FDG-PET and low dose CT scans were performed on all participants. Brain glucose metabolism was evaluated by 18 F-FDG uptake in the whole brain, cortex, basal ganglia, and cerebellum 120 min after injection. ROVER software was used for image analysis and regions of interest masks were applied via an adaptive threshold system. ANOVA tests and t -tests were performed to assess the respective differences between the four groups. Generally, the HIV+/CO+ group (group A) displayed the lowest levels of uptake whereas the HIV-/CO- group (group D) showed the highest; the HIV+/CO- and HIV-/CO+ groups (groups B and C) showed intermediate levels of activity across the whole brain, cortex, basal ganglia, and cerebellum. HIV infection and cocaine usage were independently associated with a decrease in brain glucose uptake as measured by 18 F-FDG PET/CT. When combined, positive HIV status and cocaine patients showed the most decreased 18 F-FDG uptake.
Identifiants
pubmed: 36727840
doi: 10.1097/QAD.0000000000003485
pii: 00002030-202305010-00006
pmc: PMC10090338
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Glucose
IY9XDZ35W2
Radiopharmaceuticals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
905-912Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Références
Aceijas C, Stimson GV, Hickman M, Rhodes T. United Nations Reference Group on HIV/AIDS Prevention and Care among IDU in Developing and Transitional Countries. Global overview of injecting drug use and HIV infection among injecting drug users . AIDS 2004; 18:2295–2303.
He H, Ou Z, Yu D, Li Y, Liang Y, He W, et al. Spatial and temporal trends in HIV/AIDS burden among worldwide regions from 1990 to 2019: a secondary analysis of the global burden of disease study 2019 . Front Med (Lausanne) 2022; 9:808318.
Peacock A, Leung J, Larney S, Colledge S, Hickman M, Rehm J, et al. Global statistics on alcohol, tobacco and illicit drug use: 2017 status report . Addiction 2018; 113:1905–1926.
GBD 2016 Alcohol and Drug Use Collaborators. The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 . Lancet Psychiatry 2018; 5:987–1012.
Durvasula R, Miller TR. Substance abuse treatment in persons with HIV/AIDS: challenges in managing triple diagnosis . Behav Med 2014; 40:43–52.
Naif HM. Pathogenesis of HIV infection . Infect Dis Rep 2013; 5:e6.
Maeda Y, Takemura T, Chikata T, Kuwata T, Terasaw H, Fujimoto R, et al. Existence of replication-competent minor variants with different coreceptor usage in plasma from HIV-1-infected individuals . J Virol 2020; 94:e00193–220.
Hazleton JE, Berman JW, Eugenin E. Novel mechanisms of central nervous system damage in HIV infection . HIV AIDS (Auckl) 2010; 2:39–49.
Malik S, Eugenin EA. Mechanisms of HIV neuropathogenesis: role of cellular communication systems . Curr HIV Res 2016; 14:400–411.
Cui C, Shurtleff D, Harris RA. Neuroimmune mechanisms of alcohol and drug addiction . Int Rev Neurobiol 2014; 118:1–12.
Korthuis PT, King C, Cook RR, Khuyen TT, Kunkel LE, Bart G, et al. HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, noninferiority trial . Lancet HIV 2021; 8:e67–e76.
Dong Y, Nestler EJ. The neural rejuvenation hypothesis of cocaine addiction . Trends Pharmacol Sci 2014; 35:374–383.
Jonkman S, Kenny P. Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs . Neuropsychopharmacol 2012; 38:198–211.
Sokoloff L. Energetics of functional activation in neural tissues . Neurochem Res 1999; 24:321–329.
Ioannides ZA, Thomas P, Langguth D, Kubler P, Henderson RD. The utility of FDG-PET in complex neurological conditions . Intern Med J 2017; 47:1460–1462.
Volkow ND, Wang GJ, Fowler JS, Franceschi D, Thanos PK, Wong C, et al. Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions . Life Sci 2000; 66:L161–L167.
Volkow ND, Tomasi D, Wang GJ, Logan J, Alexoff DL, Jayne M, et al. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers . Mol Psychiatry 2014; 19:1037–1043.
Volkow ND, Hitzemann R, Wang GJ, Fowler JS, Wolf AP, Dewey SL, et al. Long-term frontal brain metabolic changes in cocaine abusers . Synapse 1992; 11:184–190.
Mioni G, Sanguin N, Madeo G, Cardullo S. Time perception in cocaine-dependent patients . Brain Sci 2022; 12:745.
Newberg A, Alavi A, Reivich M. Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders . Semin Nucl Med 2002; 32:13–34.
Henry PK, Murnane KS, Votaw JR, Howell LL. Acute brain metabolic effects of cocaine in rhesus monkeys with a history of cocaine use . Brain Imaging Behav 2010; 4:212–219.
American Psychiatric Association, American Psychiatric Association. Diagnostic and statistical manual of mental disorders . 2013; DSM-V.
Volkow ND, Fowler JS, Wolf AP, Hitzemann R, Dewey S, Bendriem B, et al. Changes in brain glucose metabolism in cocaine dependence and withdrawal . Am J Psychiatry 1991; 148:621–626.
Sathekge M, Maes A, Van de Wiele C. FDG-PET imaging in HIV infection and tuberculosis . Semin Nucl Med 2013; 43:349–366.
Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation--current and emerging clinical applications . Clin Radiol 2015; 70:787–800.