A Discordant Pattern of Uptake on 68 Ga-PSMA PET/CT Versus 18 F-Fluciclovine PET/CT in Radiation-Induced Hepatitis : Implications for Early Postradiotherapy Imaging-Based Response Assessment.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
01 Apr 2023
01 Apr 2023
Historique:
pubmed:
3
2
2023
medline:
4
3
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
A 62-year-old woman with right-sided invasive lobular breast carcinoma completed external beam radiotherapy 6 weeks before undergoing a 68 Ga-PSMA PET/CT and 18 F-fluciclovine PET/CT scan as part of an ongoing clinical trial (NCT04750473) assessing the performance of these molecular imaging modalities in invasive lobular breast carcinoma. The 68 Ga-PSMA PET/CT demonstrated a band-like area of increased radiotracer uptake in the dome of the right lobe of the liver anteriorly, whereas 18 F-fluciclovine PET/CT done a day later revealed photopenia in the corresponding area of the liver. The external beam radiotherapy plan confirmed that the radiotherapy field overlaid the region of the hepatic discordant radiotracer uptake on the PET/CT scans.
Identifiants
pubmed: 36728139
doi: 10.1097/RLU.0000000000004565
pii: 00003072-202304000-00048
doi:
Substances chimiques
Gallium-68
98B30EPP5S
Gallium Radioisotopes
0
fluciclovine F-18
38R1Q0L1ZE
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202-e203Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: Fluciclovine doses were provided by Blue Earth Diagnostics, Inc. PSMA-11 cold kits were provided by Telix Pharmaceuticals (US) Inc. Study funded by NIH R21CA256280.
Références
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