Investigating the Link Between Visual Quality and Vision-Related Quality of Life in Patients With Keratoconus.
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Oct 2023
01 Oct 2023
Historique:
received:
23
06
2022
accepted:
15
10
2022
medline:
7
9
2023
pubmed:
3
2
2023
entrez:
2
2
2023
Statut:
ppublish
Résumé
The purpose of the study was to investigate the optical and visual determinants of vision-related quality of life (VR-QoL) in patients with keratoconus. A cross-sectional case-control study was conducted at the Department of Ophthalmology, Antwerp University Hospital, Belgium. Patients previously diagnosed with keratoconus and healthy emmetropic or ametropic volunteers were included. Patients younger than 18 years, with ametropia of more than ±10 D, or with a history of corneal surgery or relevant ocular comorbidity limiting visual acuity were excluded. Assessment included autorefraction, high-contrast visual acuity testing, corneal imaging, intraocular straylight analysis, contrast sensitivity, aberrometry, and the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25). The Rasch-modified visual functioning scale (VFS) and socio-emotional scale were used to quantify VR-QoL. Stepwise linear regression was used to investigate the association between the clinical variables and VR-QoL. Seventy-seven patients with keratoconus (77 pairs of eyes) and 77 age-matched and sex-matched controls were included in the study. The scores on the VFS and the SES were significantly lower in patients with keratoconus compared with controls ( P < 0.001). Higher-order and lower-order aberrations, high-contrast visual acuity, and contrast sensitivity were poorer in patients with keratoconus ( P < 0.001). Bivariate analyses showed that spectacle-corrected high-contrast visual acuity, higher spatial frequency contrast sensitivity, and higher-order aberration metrics were strong predictors of SES ( P < 0.001) and of VFS ( P < 0.001). Higher-order aberration of the worse eye was the strongest predictor for both SES (b = 0.310, P < 0.001) and VFS (b = 0.638, P < 0.001) on stepwise regression. Contrast sensitivity was not included in the stepwise regression because of insufficient data in the keratoconus group (33/77 patients; 42.9%). Both higher and lower aberration showed a strong correlation with VR-QoL, surpassing high-contrast visual acuity. These findings underline the importance of visual quality measures within keratoconus research and clinical care.
Identifiants
pubmed: 36729659
doi: 10.1097/ICO.0000000000003200
pii: 00003226-202310000-00013
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1280-1285Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no funding or conflicts of interest to disclose.
Références
Kymes SM, Walline JJ, Zadnik K, et al. Collaborative longitudinal evaluation of keratoconus study: quality of life in keratoconus. Am J Ophthalmol. 2004;138:527–535.
Godefrooij DA, de Wit GA, Uiterwaal CS, et al. Age-specific Incidence and prevalence of keratoconus: a nationwide registration study. Am J Ophthalmol. 2017;175:169–172.
Chan E, Chong EW, Lingham G, et al. Prevalence of keratoconus based on scheimpflug imaging: the raine study. Ophthalmology. 2021;128:515–521.
Kandel H, Pesudovs K, Watson SL. Measurement of quality of life in keratoconus. Cornea 2020;39:386–393.
Gothwal VK, Gujar R, Pesudovs K, et al. Factors affecting quality of life in keratoconus. Ophthalmic Physiol Opt. 2022;42:986–997.
Adams RJ, Courage ML. Using a single test to measure human contrast sensitivity from early childhood to maturity. Vis Res. 2002;42:1205–1210.
Tan JCK, Nguyen V, Fenwick E, et al. Vision-related quality of life in keratoconus: a save sight keratoconus registry study. Cornea. 2019;38:600–604.
Panthier C, Moran S, Bourges JL. Evaluation of vision-related quality of life in keratoconus patients, and associated impact of keratoconus severity indicators. Graefes Arch Clin Exp Ophthalmol. 2020;258:1459–1468.
Saunier V, Mercier AE, Gaboriau T, et al. Vision-related quality of life and dependency in French keratoconus patients: impact study. J Cataract Refract Surg. 2017;43:1582–1590,
Shneor E, Pinero DP, Doron R. Contrast sensitivity and higher-order aberrations in keratoconus subjects. Sci Rep. 2021;11:12971.
Belin MW, Duncan JK. Keratoconus: the ABCD grading system. Klin Monbl Augenheilkd. 2016;233:701–707.
Franssen L, Coppens JE, van den Berg TJTP. Compensation comparison method for assessment of retinal straylight. Invest Ophthalmol Vis Sci. 2006;47:768–776.
Van der Sterre W, Verezen CA, Meulendijks CFM, et al. National Eye Institute Visual Functioning Questionnaire–25, Nederlandse Consensus Vertaling (VFQ-25/NL). 2001. Available at: https://docplayer.nl/333579-National-eye-institute-visual-functioning-questionnaire-25-nederlandse-consensus-vertaling-vfq-25-nl.html
Mangione CM, Lee PP, Pitts J, et al. Psychometric properties of the National Eye Institute Visual Function Questionnaire (NEI-VFQ). Arch Ophthalmol. 1998;116:1496–1504.
Petrillo J, Bressler NM, Lamoureux E, et al. Development of a new Rasch-based scoring algorithm for the national eye Institute visual functioning questionnaire to improve its interpretability. Health Qual Life Outcomes 2017; 15: 157.
Pesudovs K, Gothwal VK, Wright T, et al. Remediating serious flaws in the National Eye Institute Visual Function Questionnaire. J Cataract Refract Surg. 2010;36:718–732.
Kutner MH, ed. Applied Linear Statistical Models. New York, NY: McGraw-Hill/Irwin. 2005.
Liduma S, Luguzis A, Krumina G. The impact of irregular corneal shape parameters on visual acuity and contrast sensitivity. BMC Ophthalmol. 2020;20:466.
Jones-Jordan LA, Walline JJ, Sinnott TL, et al. Asymmetry in keratoconus and vision-related quality of life. Cornea. 2013;32:267–272.
Maeda N, Fujikado T, Kuroda T, et al. Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus. Ophthalmology 2002;109:1996–2003.
Jafri B, Li X, Yang H, et al. Higher order wavefront aberrations and topography in early and suspected keratoconus. J Refract Surg. 2007;23:774–781.
Lim L, Wei RH, Chan WK, et al. Evaluation of higher order ocular aberrations in patients with keratoconus. J Refract Surg. 2007;23:825–828.
Applegate RA, Hilmantel G, Howland HC, et al. Corneal first surface optical aberrations and visual performance. J Refract Surg. 2000;16:507–514.
Okamoto C, Okamoto F, Samejima T, et al. Higher-order wavefront aberration and letter-contrast sensitivity in keratoconus. Eye. 2008;22:1488–1492.
Bayraktar Bilen N, Hepsen IF, Arce CG. Correlation between visual function and refractive, topographic, pachymetric and aberrometric data in eyes with keratoconus. Int J Ophthalmol. 2016;9:1127–1133.
Pircher N, Pachala M, Prager F, et al. Changes in straylight and densitometry values after corneal collagen crosslinking. J Cataract Refract Surg. 2015;41:1038–1043.
Mihashi T, Hirohara Y, Bessho K, et al. Intensity analysis of Hartmann-Shack images in cataractous, keratoconic, and normal eyes to investigate light scattering. Jpn J Ophthalmol. 2006;50:323–333.
Jinabhai A, O'Donnell C, Radhakrishnan H, et al. Forward light scatter and contrast sensitivity in keratoconic patients. Cont Lens Anterior Eye. 2012;35:22–27.