Association of BMAL1 clock gene polymorphisms with fasting glucose in children.

Adult Child Humans ARNTL Transcription Factors / genetics Cross-Sectional Studies Diabetes Mellitus, Type 2 Fasting Glucose Obesity / genetics Polymorphism, Single Nucleotide

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
08 2023
Historique:
received: 11 07 2022
accepted: 18 12 2022
revised: 02 11 2022
medline: 31 7 2023
pubmed: 3 2 2023
entrez: 2 2 2023
Statut: ppublish

Résumé

The brain and muscle Arnt-like protein-1 (BMAL1) gene is an important circadian clock gene and previous studies have found that certain polymorphisms are associated with type 2 diabetes in adults. However, it remains unknown if such polymorphisms can affect fasting glucose in children and if other factors modify the associations. A school-based cross-sectional study with 947 Chinese children was conducted. A multivariable linear regression model was used to analyze the association between BMAL1 gene polymorphisms and fasting glucose level. After adjusting for age, sex, body mass index (BMI), physical activity, and unhealthy diet, GG genotype carriers of BMAL1 rs3789327 had higher fasting glucose than AA/GA genotype carriers (b = 0.101, SE = 0.050, P = 0.045). Adjusting for the same confounders, rs3816358 was shown to be significantly associated with fasting glucose (b = 0.060, SE = 0.028, P = 0.032). Furthermore, a significant interaction between rs3789327 and nutritional status on fasting glucose was identified (P BMAL1 polymorphisms were significantly associated with the fasting glucose level in children. Additionally, the observed interaction between nutritional status and BMAL1 supports promoting an optimal BMI in children genetically predisposed to higher glucose level. Polymorphisms in the essential circadian clock gene BMAL1 were associated with fasting blood glucose levels in children. Additionally, there was a significant interaction between nutritional status and BMAL1 affecting fasting glucose levels. BMAL1 rs3789327 was associated with fasting glucose only in overweight/obese children. This finding could bring novel insights into mechanisms by which nutritional status influences fasting glucose in children.

Sections du résumé

BACKGROUND
The brain and muscle Arnt-like protein-1 (BMAL1) gene is an important circadian clock gene and previous studies have found that certain polymorphisms are associated with type 2 diabetes in adults. However, it remains unknown if such polymorphisms can affect fasting glucose in children and if other factors modify the associations.
METHODS
A school-based cross-sectional study with 947 Chinese children was conducted. A multivariable linear regression model was used to analyze the association between BMAL1 gene polymorphisms and fasting glucose level.
RESULTS
After adjusting for age, sex, body mass index (BMI), physical activity, and unhealthy diet, GG genotype carriers of BMAL1 rs3789327 had higher fasting glucose than AA/GA genotype carriers (b = 0.101, SE = 0.050, P = 0.045). Adjusting for the same confounders, rs3816358 was shown to be significantly associated with fasting glucose (b = 0.060, SE = 0.028, P = 0.032). Furthermore, a significant interaction between rs3789327 and nutritional status on fasting glucose was identified (P
CONCLUSIONS
BMAL1 polymorphisms were significantly associated with the fasting glucose level in children. Additionally, the observed interaction between nutritional status and BMAL1 supports promoting an optimal BMI in children genetically predisposed to higher glucose level.
IMPACT
Polymorphisms in the essential circadian clock gene BMAL1 were associated with fasting blood glucose levels in children. Additionally, there was a significant interaction between nutritional status and BMAL1 affecting fasting glucose levels. BMAL1 rs3789327 was associated with fasting glucose only in overweight/obese children. This finding could bring novel insights into mechanisms by which nutritional status influences fasting glucose in children.

Identifiants

DOI: 10.1038/s41390-023-02467-8 PMID: 36732647 PMC: PMC10382306
pubmed: 36732647
doi: 10.1038/s41390-023-02467-8
pii: 10.1038/s41390-023-02467-8
pmc: PMC10382306
doi:

Substances chimiques

ARNTL Transcription Factors 0
Glucose IY9XDZ35W2
BMAL1 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

653-659

Informations de copyright

© 2023. The Author(s).

Références

Obesity (Silver Spring). 2013 Sep;21(9):1908-14
pubmed: 23686756
Diabetes Res Clin Pract. 2015 Dec;110(3):301-8
pubmed: 26497775
Biochem Biophys Res Commun. 2002 Jan 25;290(3):933-41
pubmed: 11798163
J Clin Med. 2020 Feb 10;9(2):
pubmed: 32050674
Obes Facts. 2021;14(3):271-282
pubmed: 33951670
Diabetologia. 2011 Jan;54(1):120-4
pubmed: 20890745
Br J Nutr. 2018 Oct;120(7):813-819
pubmed: 30153872
Biomed Res Int. 2020 Sep 7;2020:9803024
pubmed: 32964049
Clin Exp Hypertens. 2020 May 18;42(4):371-375
pubmed: 31612734
Int J Cardiol Heart Vasc. 2021 Jun 03;34:100808
pubmed: 34141862
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E859-E868
pubmed: 28096338
PLoS One. 2018 Jan 11;13(1):e0190601
pubmed: 29324865
Pediatr Res. 2019 Sep;86(3):389-395
pubmed: 31003232
Antioxid Redox Signal. 2017 Apr 1;26(10):501-518
pubmed: 27225690
Endocrinology. 2005 Dec;146(12):5631-6
pubmed: 16166217
Pediatr Res. 2022 May;91(6):1595-1599
pubmed: 33935285
Annu Rev Genomics Hum Genet. 2004;5:407-41
pubmed: 15485355
Diabetes. 2021 Jan;70(1):143-154
pubmed: 33087455
Science. 2015 Nov 6;350(6261):aac4250
pubmed: 26542580
Pediatr Diabetes. 2018 May;19(3):356-365
pubmed: 29193487
Diabetes Care. 2010 Mar;33(3):670-5
pubmed: 20009096
Diabetes. 2001 Jun;50(6):1237-43
pubmed: 11375322
PLoS One. 2019 May 30;14(5):e0216950
pubmed: 31145748
Science. 2005 May 13;308(5724):1043-5
pubmed: 15845877
Chronobiol Int. 2014 Jul;31(6):770-8
pubmed: 24673294
Hypertens Res. 2015 Feb;38(2):155-62
pubmed: 25410879
Sleep. 2013 Mar 01;36(3):431-46
pubmed: 23449886
Pediatrics. 2013 Feb;131(2):364-82
pubmed: 23359574
Diabetes Res Clin Pract. 2013 Feb;99(2):151-7
pubmed: 23206673
EMBO J. 2019 Apr 15;38(8):
pubmed: 30842096
Front Endocrinol (Lausanne). 2021 Sep 07;12:722123
pubmed: 34557162
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
Diabetes Obes Metab. 2004 May;6(3):187-94
pubmed: 15056126
PLoS One. 2011;6(9):e25231
pubmed: 21966465
Lancet Public Health. 2018 Aug;3(8):e365-e373
pubmed: 30030110
Biomed Environ Sci. 2005 Dec;18(6):390-400
pubmed: 16544521
Bioinformation. 2008;3(3):139-41
pubmed: 19238253
Sleep. 2017 Apr 1;40(4):
pubmed: 28329091
Chronobiol Int. 2015;32(10):1469-76
pubmed: 26595483
Diabetol Metab Syndr. 2017 Jan 19;9:7
pubmed: 28123453
Metabolism. 2012 Jul;61(7):978-85
pubmed: 22304835
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14412-7
pubmed: 17728404
Zhonghua Er Ke Za Zhi. 2020 Jun 2;58(6):447-454
pubmed: 32521955
PLoS One. 2017 Mar 15;12(3):e0173861
pubmed: 28296937
Sci Rep. 2020 May 12;10(1):7859
pubmed: 32398715
Mol Ecol. 2002 Feb;11(2):155-65
pubmed: 11856418

Auteurs

Yi-De Yang (YD)

Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.

Yuan Zeng (Y)

Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.

Jian Li (J)

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, 410013, Changsha, China.

Jun-Hua Zhou (JH)

Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.

Quan-Yuan He (QY)

Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.

Chan-Juan Zheng (CJ)

Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, 410006, Changsha, China.
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, 410081, Changsha, China.

Christoph Reichetzeder (C)

Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
HMU - Health and Medical University, Potsdam, Germany.

Bernhard K Krämer (BK)

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.

Berthold Hocher (B)

Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, 410013, Changsha, China. berthold.hocher@medma.uni-heidelberg.de.
Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany. berthold.hocher@medma.uni-heidelberg.de.
Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. berthold.hocher@medma.uni-heidelberg.de.
Institute of Medical Diagnostics, IMD Berlin, Berlin, Germany. berthold.hocher@medma.uni-heidelberg.de.
ORCID: 0000-0001-8143-0579

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteurs de transcription ARNTL › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › Jeûne › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Association of BMAL1 clock gene polymorphisms...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Association of BMAL1 clock gene polymorphisms...