The Evaluation of Risk Factors for Vancomycin-Resistant Enterococcus Colonization and Infection Among Mixed Adult Intensive Care Unit Patients.
antimicrobial resistance infectious diseases
length of stay in icu
mdro colonization
medical intensive care unit (micu)
vancomycin resistant enterococcus (vre)
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
accepted:
31
12
2022
entrez:
3
2
2023
pubmed:
4
2
2023
medline:
4
2
2023
Statut:
epublish
Résumé
Background and objective Despite the adherence to strict infection control measures, vancomycin-resistant enterococcus (VRE) colonization and VRE infections are still important problems nowadays. However, there are only a limited number of studies examining the factors causing the transformation of VRE colonization to VRE infection in the intensive care unit (ICU). The aim of this study is to delineate the prevalence of VRE colonization and its transformation into infection and the risk factors leading to infection. Methods Patients admitted to the third-level mixed-type ICU from 2012 to 2015 for at least 24 hours and acquired VRE colonization and VRE infection, both during and after their admission, were included in the study, and their medical records were examined retrospectively. VRE rectal swabs were taken weekly from each patient on admission and discharge from the ICU. If the VRE-positive patient was detected negative for VRE on the rectal swap taken three times in total as a surveillance culture successively, this patient was accepted as VRE negative. Demographic data, Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores, invasive procedures, treatments (corticosteroid, antibiotic, etc.), nutrition types, laboratory results, and ICU results were recorded. Results Among 1730 patients admitted to ICU, 101 (5.8%) were found to carry VRE colonization. Twelve (11.8%) out of 101 patients colonized with VRE developed VRE infection. About 56.4% had urinary tract infections, 68.3% had pneumonia, 15.8% had surgical site infections, and 24.8% had catheter-associated infections among these infected patients. The most prevalent factor was
Identifiants
pubmed: 36733561
doi: 10.7759/cureus.33210
pmc: PMC9887662
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e33210Informations de copyright
Copyright © 2023, Doganci et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Eur J Pediatr. 1998 Jan;157(1):20-7
pubmed: 9461358
Clin Infect Dis. 1996 Oct;23(4):767-72
pubmed: 8909842
Braz J Infect Dis. 2005 Feb;9(1):64-9
pubmed: 15947849
PLoS One. 2012;7(10):e47297
pubmed: 23071778
Support Care Cancer. 2010 Feb;19(2):231-7
pubmed: 20069435
PLoS One. 2013 Sep 27;8(9):e75658
pubmed: 24086603
Infect Dis Clin North Am. 1997 Jun;11(2):367-84
pubmed: 9187952
Am J Infect Control. 2000 Aug;28(4):282-5
pubmed: 10926704
Clin Microbiol Rev. 2000 Oct;13(4):686-707
pubmed: 11023964
Clin Infect Dis. 2002 Nov 15;35(10):1139-46
pubmed: 12410472
Infect Control Hosp Epidemiol. 2000 Sep;21(9):575-82
pubmed: 11001260
J Antimicrob Chemother. 2004 Jul;54(1):221-4
pubmed: 15190030
Clin Microbiol Infect. 2008 Jan;14(1):14-21
pubmed: 18005178
Infect Control Hosp Epidemiol. 1996 Sep;17(9):576-80
pubmed: 8880229
Mem Inst Oswaldo Cruz. 2012 Feb;107(1):57-63
pubmed: 22310536
Arch Intern Med. 1999 Jul 12;159(13):1467-72
pubmed: 10399898
Ann Intern Med. 1992 Jul 15;117(2):112-6
pubmed: 1605425
Infection. 2014 Dec;42(6):1013-22
pubmed: 25143193
Clin Infect Dis. 1997 Apr;24(4):545-54; quiz 555-6
pubmed: 9145724
Diagn Microbiol Infect Dis. 2000 Mar;36(3):145-58
pubmed: 10729656