Vaccine hesitancy decreases in rheumatic diseases, long-term concerns remain in myositis: a comparative analysis of the COVAD surveys.

Humans COVID-19 Vaccines / adverse effects Vaccination Hesitancy COVID-19 / epidemiology Myositis / epidemiology Rheumatic Diseases Autoimmune Diseases Self Report Vaccination

COVID-19 vaccines autoimmune disease idiopathic inflammatory myopathies registries vaccine hesitancy

Journal

Rheumatology (Oxford, England)

ISSN: 1462-0332

Titre abrégé: Rheumatology (Oxford)

Pays: England

ID NLM: 100883501

Informations de publication

Date de publication:
03 10 2023

Historique:

received: 10 11 2022

accepted: 23 01 2023

medline: 5 10 2023

pubmed: 4 2 2023

entrez: 3 2 2023

Statut: ppublish

Résumé

COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for hesitancy in patients with IIMs, other AIRDs, non-rheumatic autoimmune diseases (nrAIDs) and healthy controls (HCs), using data from the two international COVID-19 Vaccination in Autoimmune Diseases (COVAD) e-surveys. The first and second COVAD patient self-reported e-surveys were circulated from March to December 2021, and February to June 2022 (ongoing). We collected data on demographics, comorbidities, COVID-19 infection and vaccination history, reasons for hesitancy, and patient reported outcomes. Predictors of hesitancy were analysed using regression models in different groups. We analysed data from 18 882 (COVAD-1) and 7666 (COVAD-2) respondents. Reassuringly, hesitancy decreased from 2021 (16.5%) to 2022 (5.1%) (OR: 0.26; 95% CI: 0.24, 0.30, P < 0.001). However, concerns/fear over long-term safety had increased (OR: 3.6; 95% CI: 2.9, 4.6, P < 0.01). We noted with concern greater skepticism over vaccine science among patients with IIMs than AIRDs (OR: 1.8; 95% CI: 1.08, 3.2, P = 0.023) and HCs (OR: 4; 95% CI: 1.9, 8.1, P < 0.001), as well as more long-term safety concerns/fear (IIMs vs AIRDs - OR: 1.9; 95% CI: 1.2, 2.9, P = 0.001; IIMs vs HCs - OR: 5.4 95% CI: 3, 9.6, P < 0.001). Caucasians [OR 4.2 (1.7-10.3)] were likely to be more hesitant, while those with better PROMIS physical health score were less hesitant [OR 0.9 (0.8-0.97)]. Vaccine hesitancy has decreased from 2021 to 2022, long-term safety concerns remain among patients with IIMs, particularly in Caucasians and those with poor physical function.

Identifiants

DOI: 10.1093/rheumatology/kead057 PMID: 36734536

pubmed: 36734536

pii: 7025490

doi: 10.1093/rheumatology/kead057

doi:

Substances chimiques

COVID-19 Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

3291-3301

Subventions

Organisme : Versus Arthritis

ID : 21992

Pays : United Kingdom

Organisme : Department of Health

Pays : United Kingdom

Investigateurs

Sinan Kardes (S)

Laura Andreoli (L)

Daniele Lini (D)

Karen Screiber (K)

Melinda Nagy Vince (MN)

Yogesh Preet Singh (YP)

Rajiv Ranjan (R)

Avinash Jain (A)

Sapan C Pandya (SC)

Rakesh Kumar Pilania (RK)

Aman Sharma (A)

M Manesh Manoj (M)

Vikas Gupta (V)

Chengappa G Kavadichanda (CG)

Pradeepta Sekhar Patro (PS)

Sajal Ajmani (S)

Sanat Phatak (S)

Rudra Prosad Goswami (RP)

Abhra Chandra Chowdhury (AC)

Ashish Jacob Mathew (AJ)

Padnamabha Shenoy (P)

Ajay Asranna (A)

Keerthi Talari Bommakanti (KT)

Anuj Shukla (A)

Arunkumar R Pande (AR)

Kunal Chandwar (K)

Akanksha Ghodke (A)

Hiya Boro (H)

Zoha Zahid Fazal (ZZ)

Döndü Üsküdar Cansu (DÜ)

Reşit Yıldırım (R)

Armen Yuri Gasparyan (AY)

Nicoletta Del Papa (N)

Gianluca Sambataro (G)

Atzeni Fabiola (A)

Marcello Govoni (M)

Simone Parisi (S)

Elena Bartoloni Bocci (EB)

Gian Domenico Sebastiani (GD)

Enrico Fusaro (E)

Marco Sebastiani (M)

Luca Quartuccio (L)

Franco Franceschini (F)

Pier Paolo Sainaghi (PP)

Giovanni Orsolini (G)

Rossella De Angelis (R)

Maria Giovanna Danielli (MG)

Vincenzo Venerito (V)

Silvia Grignaschi (S)

Alessandro Giollo (A)

Alessia Alluno (A)

Florenzo Ioannone (F)

Marco Fornaro (M)

Lisa S Traboco (LS)

Suryo Anggoro Kusumo Wibowo (SAK)

Jesús Loarce-Martos (J)

Sergio Prieto-González (S)

Raquel Aranega Gonzalez (RA)

Akira Yoshida (A)

Ran Nakashima (R)

Shinji Sato (S)

Naoki Kimura (N)

Yuko Kaneko (Y)

Takahisa Gono (T)

Stylianos Tomaras (S)

Fabian Nikolai Proft (FN)

Marie-Therese Holzer (MT)

Margarita Aleksandrovna Gromova (MA)

Or Aharonov (O)

Zoltán Griger (Z)

Ihsane Hmamouchi (I)

Imane El Bouchti (I)

Zineb Baba (Z)

Margherita Giannini (M)

François Maurier (F)

Julien Campagne (J)

Alain Meyer (A)

Daman Langguth (D)

Vidya Limaye (V)

Merrilee Needham (M)

Nilesh Srivastav (N)

Marie Hudson (M)

Océane Landon-Cardinal (O)

Wilmer Gerardo Rojas Zuleta (WGR)

Álvaro Arbeláez (Á)

Javier Cajas (J)

José António Pereira Silva (JAP)

João Eurico Fonseca (JE)

Olena Zimba (O)

Doskaliuk Bohdana (D)

Uyi Ima-Edomwonyi (U)

Ibukunoluwa Dedeke (I)

Emorinken Airenakho (E)

Nwankwo Henry Madu (NH)

Abubakar Yerima (A)

Hakeem Olaosebikan (H)

A Becky (A)

Oruma Devi Koussougbo (OD)

Elisa Palalane (E)

Ho So (H)

Manuel Francisco Ugarte-Gil (MF)

Lyn Chinchay (L)

José Proaño Bernaola (JP)

Victorio Pimentel (V)

Hanan Mohammed Fathi (HM)

Reem Hamdy A Mohammed (RHA)

Ghita Harifi (G)

Yurilís Fuentes-Silva (Y)

Karoll Cabriza (K)

Jonathan Losanto (J)

Nelly Colaman (N)

Antonio Cachafeiro-Vilar (A)

Generoso Guerra Bautista (GG)

Enrique Julio Giraldo Ho (EJG)

Raúl González (R)

Lilith Stange Nunez (LS)

M Cristian Vergara (M)

Jossiell Then Báez (JT)

Hugo Alonzo (H)

Carlos Benito Santiago Pastelin (CBS)

Rodrigo García Salinas (RG)

Alejandro Quiñónez Obiols (AQ)

Nilmo Chávez (N)

Andrea Bran Ordóñez (AB)

Sandra Argueta (S)

Gil Alberto Reyes Llerena (GAR)

Radames Sierra-Zorita (R)

Dina Arrieta (D)

Eduardo Romero Hidalgo (ER)

Ricardo Saenz (R)

M Idania Escalante (M)

Roberto Morales (R)

Wendy Calapaqui (W)

Ivonne Quezada (I)

Gabriela Arredondo (G)