Lack of Cyclin E1 in hepatocytes aggravates ethanol-induced liver injury and hepatic steatosis in experimental murine model of acute and chronic alcohol-associated liver disease.
ADH
ALD
ALDH
CR-8
Cyclin E
Ethanol
Lieber-DeCarli diet
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
13
09
2022
revised:
13
01
2023
accepted:
17
01
2023
pubmed:
4
2
2023
medline:
7
3
2023
entrez:
3
2
2023
Statut:
ppublish
Résumé
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one of the central players in cell cycle progression. We recently showed its crucial role for initiation of liver fibrosis and hepatocarcinogenesis. In the present study, we investigated the role of Cyclin E1 in the development of alcohol-associated liver disease (ALD). Mice with constitutive (E1 The administration of acute EtOH binge and chronic LDE diet to E1 Our data point to a novel unexpected role of Cyclin E1 in hepatocytes for alcohol metabolism, which seems to be independent of the canonical Cyclin E1/Cdk2 function as a cell cycle regulator.
Sections du résumé
BACKGROUND
Cyclin E1 is the regulatory subunit of cyclin-dependent kinase 2 (Cdk2) and one of the central players in cell cycle progression. We recently showed its crucial role for initiation of liver fibrosis and hepatocarcinogenesis. In the present study, we investigated the role of Cyclin E1 in the development of alcohol-associated liver disease (ALD).
METHODS
Mice with constitutive (E1
RESULTS
The administration of acute EtOH binge and chronic LDE diet to E1
CONCLUSION
Our data point to a novel unexpected role of Cyclin E1 in hepatocytes for alcohol metabolism, which seems to be independent of the canonical Cyclin E1/Cdk2 function as a cell cycle regulator.
Identifiants
pubmed: 36736843
pii: S0925-4439(23)00010-8
doi: 10.1016/j.bbadis.2023.166646
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
cyclin E1, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166646Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.