Food effects on gastrointestinal physiology and drug absorption.
Beverage
Bioavailability
Drug absorption
Drug interaction
Food
Gastrointestinal physiology
Journal
Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Titre abrégé: Drug Metab Pharmacokinet
Pays: England
ID NLM: 101164773
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
12
10
2022
revised:
01
12
2022
accepted:
13
12
2022
pubmed:
4
2
2023
medline:
15
3
2023
entrez:
3
2
2023
Statut:
ppublish
Résumé
Food ingestion affects the oral absorption of many drugs in humans. In this review article, we summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo performance of orally administered solid dosage forms in fasted and fed states in humans. In particular, we discuss the effects of food ingestion on fluid characteristics (pH, bile concentration, and volume) in the stomach and small intestine, GI transit of water and dosage forms, and microbiota. Additionally, case examples of food effects on GI physiology and subsequent changes in oral drug absorption are provided. Furthermore, the effects of food, especially fruit juices (e.g., grapefruit, orange, apple) and green tea, on transporter-mediated permeation and enzyme-catalyzed metabolism of drugs in intestinal epithelial cells are also summarized comprehensively.
Identifiants
pubmed: 36737277
pii: S1347-4367(22)00045-3
doi: 10.1016/j.dmpk.2022.100488
pii:
doi:
Substances chimiques
Membrane Transport Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100488Informations de copyright
Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Atsushi Kambayashi is an employee of Astellas Pharma Inc. but has no conflict of interest related to this work. Yoshiyuki Shirasaka declares no conflict of interest.