The kidney-brain pathogenic axis in severe falciparum malaria.

Humans Malaria, Cerebral / complications Malaria, Falciparum / drug therapy Kidney / pathology Acute Kidney Injury / etiology Brain Plasmodium falciparum
Plasmodium falciparum brain, kidney injury cerebral malaria pathogenesis severe malaria

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
03 2023
Historique:
received: 08 11 2022
revised: 13 01 2023
accepted: 13 01 2023
pubmed: 4 2 2023
medline: 22 2 2023
entrez: 3 2 2023
Statut: ppublish

Résumé

Severe falciparum malaria is a medical emergency and a leading cause of death and neurodisability in endemic areas. Common complications include acute kidney injury (AKI) and cerebral malaria, and recent studies have suggested links between kidney and brain dysfunction in Plasmodium falciparum infection. Here, we review these new findings and present the hypothesis of a pivotal pathogenic crosstalk between the kidneys and the brain in severe falciparum malaria. We highlight the evidence of a role for distant organ involvement in the development of cerebral malaria and subsequent neurocognitive impairment post-recovery, describe the challenges associated with current diagnostic shortcomings for both AKI and brain involvement in severe falciparum malaria, and explore novel potential therapeutic strategies.

Identifiants

DOI: 10.1016/j.pt.2023.01.005 PMID: 36737313
pubmed: 36737313
pii: S1471-4922(23)00009-0
doi: 10.1016/j.pt.2023.01.005
pii:
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

191-199

Subventions

Organisme : NINDS NIH HHS
ID : R21 NS127215
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS035534
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI151349
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS129234
Pays : United States
Organisme : Medical Research Council
ID : MR/S009450/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI165946
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Andrea L Conroy (AL)

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Dibyadyuti Datta (D)

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Angelika Hoffmann (A)

University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, University of Bern, Bern, Switzerland.

Samuel C Wassmer (SC)

Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. Electronic address: Sam.Wassmer@lshtm.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Infections du système nerveux central › Infections parasitaires du système nerveux central › Protozooses du système nerveux central › Paludisme cérébral › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › The kidney-brain pathogenic axis in severe...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › The kidney-brain pathogenic axis in severe...