Moonlighting proteins [ML proteins]: The pandora's box of insidious oro-dental diseases.
Enolase
GAPDH
Moonlighting protein
Streptococci
Virulence
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
23
11
2022
accepted:
27
01
2023
pubmed:
5
2
2023
medline:
21
3
2023
entrez:
4
2
2023
Statut:
ppublish
Résumé
Oral pathogens survive in the harsh niche of the oral microbiome on account of a plethora of moonlighting [ML] proteins that can multitask in the oro-mucosal layers. ML proteins are considered as the complex protein hyperspace expressed in many oral bacterial pathogens and encompass many hypothetical and experimentally evidenced proteins that can efficiently assist in the initiation and progression of various oro-dental infections. With the propensity of multi-drug resistance and biofilm formation, unravelling the mysterious functions associated with the oral ML proteins could be essential in targeting the vital oral bacteria and their associated infections. This commentary thus throws insights onto the key clues on various ML proteins that can be considered for the development of therapeutic versatility to curtail the complications caused by various oral bacterial species.
Identifiants
pubmed: 36738892
pii: S0167-4889(23)00006-X
doi: 10.1016/j.bbamcr.2023.119435
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119435Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The author declare that there is no conflict of interest.