An evaluation of Composite Reference Standard (CRS) for diagnosis of Female Genital Tuberculosis.
Acid-fast bacilli
Composite reference standard
Epithelioid granuloma
Female genital tuberculosis
Gene Xpert
Journal
The Indian journal of tuberculosis
ISSN: 0019-5707
Titre abrégé: Indian J Tuberc
Pays: India
ID NLM: 0373027
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
07
05
2021
revised:
06
08
2021
accepted:
09
03
2022
entrez:
5
2
2023
pubmed:
6
2
2023
medline:
8
2
2023
Statut:
ppublish
Résumé
Female genital tuberculosis (FGTB) is a common cause of infertility in developing countries. Its diagnosis is difficult due to its paucibacillary nature, with no single test having high sensitivity and specificity. This study is to share the experience of using Composite Reference Standard (CRS) for the diagnosis of FGTB. This is a prospective study conducted between September 2017 to June 2019, over 100 infertile females found to have FGTB on composite reference standard which consisted of acid-fast bacilli on microscopy or culture, histopathological evidence of epithelioid granuloma, positive gene Xpert on endometrial sample or definite or probable finding of FGTB on laparoscopy. A total of 100 infertile women (78% primary, 22% secondary) found to have FGTB on CRS were enrolled in this study. Mean age, body mass index, parity and duration of infertility were 28.2 years, 23.17 kg/m This study demonstrates the high reliability of use of composite reference standard for diagnosis of FGTB.
Sections du résumé
BACKGROUND
BACKGROUND
Female genital tuberculosis (FGTB) is a common cause of infertility in developing countries. Its diagnosis is difficult due to its paucibacillary nature, with no single test having high sensitivity and specificity. This study is to share the experience of using Composite Reference Standard (CRS) for the diagnosis of FGTB.
METHODS
METHODS
This is a prospective study conducted between September 2017 to June 2019, over 100 infertile females found to have FGTB on composite reference standard which consisted of acid-fast bacilli on microscopy or culture, histopathological evidence of epithelioid granuloma, positive gene Xpert on endometrial sample or definite or probable finding of FGTB on laparoscopy.
RESULTS
RESULTS
A total of 100 infertile women (78% primary, 22% secondary) found to have FGTB on CRS were enrolled in this study. Mean age, body mass index, parity and duration of infertility were 28.2 years, 23.17 kg/m
CONCLUSION
CONCLUSIONS
This study demonstrates the high reliability of use of composite reference standard for diagnosis of FGTB.
Identifiants
pubmed: 36740321
pii: S0019-5707(22)00043-9
doi: 10.1016/j.ijtb.2022.03.014
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-76Informations de copyright
Copyright © 2022 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors have none to declare.