Neurosurgical Approaches for Treatment-Resistant Obsessive-Compulsive Disorder.

Humans Obsessive-Compulsive Disorder / surgery Deep Brain Stimulation Psychotropic Drugs
DBS Neuromodulation Neurosurgery OCD

Journal

The Psychiatric clinics of North America
ISSN: 1558-3147
Titre abrégé: Psychiatr Clin North Am
Pays: United States
ID NLM: 7708110

Informations de publication

Date de publication:
03 2023
Historique:
entrez: 5 2 2023
pubmed: 6 2 2023
medline: 8 2 2023
Statut: ppublish

Résumé

Treatment-resistant obsessive-compulsive disorder (trOCD) is a severely disabling, life-threatening psychiatric disorder affecting ∼0.5% of the US population. Following the failure of multiple medical and psychotherapeutic treatment lines, patients with trOCD, like others with functional disorders, may benefit from invasive neuromodulation. Cumulative evidence suggests that disrupting abnormal hyperdirect cortico-striato-thalamo-cortical (CSTC) pathway activity offers sustainable, robust symptomatic relief in most patients. Multiple surgical approaches allow for modulation of the CSTC pathway, including stereotactic lesions and electrical stimulation. This review aims to describe the modern neurosurgical approaches for trOCD, recent advances in our understanding of pathophysiology, and future therapeutic directions.

Identifiants

DOI: 10.1016/j.psc.2022.11.002 PMID: 36740348
pubmed: 36740348
pii: S0193-953X(22)00099-5
doi: 10.1016/j.psc.2022.11.002
pii:
doi:

Substances chimiques

Psychotropic Drugs 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

121-132

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ben Shofty (B)

Department of Neurosurgery, University of Utah, 175 North Medical Drive East, 5th Floor, Salt Lake City, UT 84132, USA.

Ron Gadot (R)

Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge Street Suite 9A, Houston, TX 77030, USA.

Nicole Provenza (N)

Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge Street Suite 9A, Houston, TX 77030, USA.

Eric A Storch (EA)

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX 77030, USA.

Wayne K Goodman (WK)

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX 77030, USA.

Sameer A Sheth (SA)

Department of Neurosurgery, Baylor College of Medicine, 7200 Cambridge Street Suite 9A, Houston, TX 77030, USA; Department of Psychiatry, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX 77030, USA. Electronic address: sameer.sheth@bcm.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neurosurgical Approaches for...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Trouble obsessionnel compulsif › Neurosurgical Approaches for...
questionsmedicales.fr › Procédures de chirurgie opératoire › Stimulation cérébrale profonde › Neurosurgical Approaches for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Neurosurgical Approaches for...