[Adipocytes, adipokines and metabolic alterations in pulmonary fibrosis].

Adipocytes, adipokines et altérations métaboliques dans la fibrose pulmonaire.
Humans Adipokines Idiopathic Pulmonary Fibrosis Lung Adipocytes / metabolism Lipids
Adipocytes Adipokines Fibrose pulmonaire idiopathique Idiopathic pulmonary fibrosis Metabolic syndrome Syndrome métabolique

Journal

Revue des maladies respiratoires
ISSN: 1776-2588
Titre abrégé: Rev Mal Respir
Pays: France
ID NLM: 8408032

Informations de publication

Date de publication:
Mar 2023
Historique:
received: 05 01 2023
accepted: 06 01 2023
pubmed: 6 2 2023
medline: 28 3 2023
entrez: 5 2 2023
Statut: ppublish

Résumé

Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by severe remodeling of the lung parenchyma, with an accumulation of activated myofibroblasts and extracellular matrix, along with aberrant cellular differentiation. Within the subpleural fibrous zones, ectopic adipocyte deposits often appear. In addition, alterations in lipid homeostasis have been associated with IPF pathophysiology. In this mini-review, we will discuss the potential involvement of the adipocyte secretome and its paracrine or endocrine-based contribution to the pathophysiology of IPF, via protein or lipid mediators in particular.

Identifiants

DOI: 10.1016/j.rmr.2023.01.016 PMID: 36740493
pubmed: 36740493
pii: S0761-8425(23)00039-6
doi: 10.1016/j.rmr.2023.01.016
pii:
doi:

Substances chimiques

Adipokines 0
Lipids 0

Types de publication

Review English Abstract Journal Article

Langues

fre

Sous-ensembles de citation

IM

Pagination

225-229

Informations de copyright

Copyright © 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Auteurs

K El Husseini (K)

Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France. Electronic address: kinelhu@gmail.com.

N Poté (N)

Service d'anatomopathologie, Hôpital Bichat, AP-HP ; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

M Jaillet (M)

Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

P Mordant (P)

Service de chirurgie vasculaire et thoracique, Hôpital Bichat, AP-HP, Paris, France.

H Mal (H)

Service de pneumologie B, Hôpital Bichat, AP-HP ; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

J Frija-Masson (J)

Service de physiologie-explorations fonctionnelles respiratoires, Hôpital Bichat, AP-HP, Paris, France.

R Borie (R)

Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France.

A Cazes (A)

Service d'anatomopathologie, Hôpital Bichat, AP-HP ; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

B Crestani (B)

Service de pneumologie A, Hôpital Bichat, AP-HP ; Inserm Unit 1152, Université de Paris, Paris, France; Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

A Mailleux (A)

Inserm Unité 1152 - PHERE, Université de Paris, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › [Adipocytes, adipokines and metabolic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › [Adipocytes, adipokines and metabolic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Fibrose pulmonaire idiopathique › [Adipocytes, adipokines and metabolic...
questionsmedicales.fr › Appareil respiratoire › Poumon › [Adipocytes, adipokines and metabolic...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › [Adipocytes, adipokines and metabolic...
questionsmedicales.fr › Lipides › [Adipocytes, adipokines and metabolic...