Targeting cyclin-dependent kinases in sarcoma treatment: Current perspectives and future directions.
cdk inhibitors
cell cycle
cyclin dependent kinases (CDK)
sarcoma
target therapy
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
11
2022
accepted:
03
01
2023
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
Effective treatment of advanced/metastatic bone and soft tissue sarcomas still represents an unmet medical need. Recent advances in targeted therapies have highlighted the potential of cyclin-dependent kinases (CDK) inhibitors in several cancer types, including sarcomas. CDKs are master regulators of the cell cycle; their dysregulation is listed among the "hallmarks of cancer" and sarcomas are no exception to the rule. In this review, we report both the molecular basis, and the potential therapeutic implications for the use of CDK inhibitors in sarcoma treatment. What is more, we describe and discuss the possibility and biological rationale for combination therapies with conventional treatments, target therapy and immunotherapy, highlighting potential avenues for future research to integrate CDK inhibition in sarcoma treatment.
Identifiants
pubmed: 36741019
doi: 10.3389/fonc.2023.1095219
pmc: PMC9893281
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1095219Informations de copyright
Copyright © 2023 Merlini, Pavese, Manessi, Rabino, Tolomeo, Aliberti, D’Ambrosio and Grignani.
Déclaration de conflit d'intérêts
AM: travel expenses from PharmaMar. LA received travel expenses from PharmaMar and Lilly. GG has received fees for consulting and advisory board roles from PharmaMar, Lilly, Novartis, GSK, Bayer, and Eisai. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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