Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.
COPD
adaptive immunity
inflammation
innate immunity
lung microbiome
mucosal immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
10
2022
accepted:
28
12
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
8
2
2023
Statut:
epublish
Résumé
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global mortality, with three million deaths reported annually. This impact is expected to increase over the next 40 years, with approximately 5 million people predicted to succumb to COPD-related deaths annually. Immune mechanisms driving disease progression have not been fully elucidated. Airway microbiota have been implicated. However, it is still unclear how changes in the airway microbiome drive persistent immune activation and consequent lung damage. Mechanisms mediating microbiome-immune crosstalk in the airways remain unclear. In this review, we examine how dysbiosis mediates airway inflammation in COPD. We give a detailed account of how airway commensal bacteria interact with the mucosal innate and adaptive immune system to regulate immune responses in healthy or diseased airways. Immune-phenotyping airway microbiota could advance COPD immunotherapeutics and identify key open questions that future research must address to further such translation.
Identifiants
pubmed: 36741369
doi: 10.3389/fimmu.2022.1085551
pmc: PMC9890194
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1085551Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL146946
Pays : United States
Organisme : FIC NIH HHS
ID : R21 TW012354
Pays : United States
Informations de copyright
Copyright © 2023 Kayongo, Robertson, Siddharthan, Ntayi, Ndawula, Sande, Bagaya, Kirenga, Mayanja-Kizza, Joloba and Forslund.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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