Suicidal attempts and ideations in Kenyan adults with psychotic disorders: An observational study of frequency and associated risk factors.
Kenya
low and middle income countries
risk factors
schizophrenia
stigma
sub-Saharan Africa
suicidal attempts
suicidal ideation
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
10
2022
accepted:
28
12
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
Psychotic disorders increase the risk for premature mortality with up to 40% of this mortality attributable to suicide. Although suicidal ideation (SI) and suicidal behavior (SB) are high in persons with psychotic disorders in sub-Saharan Africa, there is limited data on the risk of suicide and associated factors among persons with psychotic disorders. We assessed SI and SB in persons with psychotic disorders, drawn from a large case-control study examining the genetics of psychotic disorders in a Kenyan population. Participants with psychotic disorders were identified using a clinical review of records, and the diagnosis was confirmed with the Mini-International Neuropsychiatric Interview (MINI). We conducted bivariate and multivariate logistic (for binary suicide outcomes) or linear regression (for suicide risk score) analysis for each of the suicide variables, with demographic and clinical variables as determinants. Out of 619 participants, any current SI or lifetime suicidal attempts was reported by 203 (32.8%) with psychotic disorders, of which 181 (29.2%) had a lifetime suicidal attempt, 60 (9.7%) had SI in the past month, and 38 (20.9%) had both. Family history of suicidality was significantly associated with an increased risk of suicidality across all the following four outcomes: SI [OR = 2.56 (95% CI: 1.34-4.88)], suicidal attempts [OR = 2.01 (95% CI: 1.31-3.06)], SI and SB [OR = 2.00 (95% CI: 1.31-3.04)], and suicide risk score [beta coefficient = 7.04 (2.72; 11.36), Suicidal ideation and SB are common in persons with psychotic disorders in this African setting and are associated with sociodemographic factors, such as young age and unemployment, and clinical factors, such as family history of suicidality. Interventions targeted at the community (e.g., economic empowerment) or at increasing access to care and treatment for persons with psychotic disorders may reduce the risk of suicide in this vulnerable population group.
Sections du résumé
Background
UNASSIGNED
Psychotic disorders increase the risk for premature mortality with up to 40% of this mortality attributable to suicide. Although suicidal ideation (SI) and suicidal behavior (SB) are high in persons with psychotic disorders in sub-Saharan Africa, there is limited data on the risk of suicide and associated factors among persons with psychotic disorders.
Methods
UNASSIGNED
We assessed SI and SB in persons with psychotic disorders, drawn from a large case-control study examining the genetics of psychotic disorders in a Kenyan population. Participants with psychotic disorders were identified using a clinical review of records, and the diagnosis was confirmed with the Mini-International Neuropsychiatric Interview (MINI). We conducted bivariate and multivariate logistic (for binary suicide outcomes) or linear regression (for suicide risk score) analysis for each of the suicide variables, with demographic and clinical variables as determinants.
Results
UNASSIGNED
Out of 619 participants, any current SI or lifetime suicidal attempts was reported by 203 (32.8%) with psychotic disorders, of which 181 (29.2%) had a lifetime suicidal attempt, 60 (9.7%) had SI in the past month, and 38 (20.9%) had both. Family history of suicidality was significantly associated with an increased risk of suicidality across all the following four outcomes: SI [OR = 2.56 (95% CI: 1.34-4.88)], suicidal attempts [OR = 2.01 (95% CI: 1.31-3.06)], SI and SB [OR = 2.00 (95% CI: 1.31-3.04)], and suicide risk score [beta coefficient = 7.04 (2.72; 11.36),
Conclusion
UNASSIGNED
Suicidal ideation and SB are common in persons with psychotic disorders in this African setting and are associated with sociodemographic factors, such as young age and unemployment, and clinical factors, such as family history of suicidality. Interventions targeted at the community (e.g., economic empowerment) or at increasing access to care and treatment for persons with psychotic disorders may reduce the risk of suicide in this vulnerable population group.
Identifiants
pubmed: 36741571
doi: 10.3389/fpsyt.2022.1085201
pmc: PMC9892760
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1085201Informations de copyright
Copyright © 2023 Ongeri, Kariuki, Nyawira, Schubart, Tijdink, Newton and Penninx.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Compr Psychiatry. 2009 Nov-Dec;50(6):496-502
pubmed: 19840586
S Afr J Psychiatr. 2022 Jan 27;28:1547
pubmed: 35169504
Acta Biomed. 2021 Oct 01;92(S6):e2021417
pubmed: 34739460
Schizophr Bull. 2018 Jun 6;44(4):787-797
pubmed: 29036388
J Epidemiol Community Health. 2003 Aug;57(8):594-600
pubmed: 12883065
J Am Acad Child Adolesc Psychiatry. 2010 Feb;49(2):114-21
pubmed: 20215933
Expert Rev Neurother. 2010 Jul;10(7):1153-64
pubmed: 20586695
Eur Psychiatry. 2015 Oct;30(7):830-6
pubmed: 26443050
J Psychopharmacol. 2010 Nov;24(4 Suppl):17-25
pubmed: 20923917
Asian J Psychiatr. 2021 Apr;58:102601
pubmed: 33611083
PLoS One. 2015 Jul 06;10(7):e0129062
pubmed: 26147965
Eur Child Adolesc Psychiatry. 2005 Dec;14(8):454-60
pubmed: 16341502
Am J Psychiatry. 1999 Oct;156(10):1590-5
pubmed: 10518171
Front Psychiatry. 2021 Dec 16;12:779684
pubmed: 34975579
Arch Suicide Res. 2012;16(4):287-302
pubmed: 23137219
Br J Psychiatry Suppl. 2007 Dec;51:s140-6
pubmed: 18055932
J Psychosom Res. 2022 Jun;157:110788
pubmed: 35334350
World Psychiatry. 2013 Feb;12(1):53-9
pubmed: 23471802
Acta Psychiatr Scand. 2021 Jan;143(1):61-71
pubmed: 33155273
Psychiatr Clin North Am. 2008 Jun;31(2):157-77
pubmed: 18439442
BMC Psychiatry. 2019 May 7;19(1):137
pubmed: 31064338
Schizophr Res. 2022 Oct;248:42-49
pubmed: 35933743
BMJ. 2004 Jul 31;329(7460):261
pubmed: 15213108
Compr Psychiatry. 1985 Jan-Feb;26(1):90-100
pubmed: 3881217
Biol Psychiatry. 2022 Feb 1;91(3):313-327
pubmed: 34861974
J Psychopharmacol. 2001 Jun;15(2):127-35
pubmed: 11448086
Schizophr Res Treatment. 2021 Apr 01;2021:6662765
pubmed: 33868728
Addiction. 2017 Jul;112(7):1250-1259
pubmed: 28192643
Scand J Psychol. 2003 Sep;44(4):373-81
pubmed: 12887559
Behav Res Ther. 1997 Nov;35(11):1039-46
pubmed: 9431735
Front Psychiatry. 2016 Jun 27;7:116
pubmed: 27445872
Medicina (Kaunas). 2019 Jul 10;55(7):
pubmed: 31295938
Soc Sci Med. 2010 Aug;71(3):517-528
pubmed: 20621748
Schizophr Res. 2016 Feb;170(2-3):271-7
pubmed: 26746862
JAMA Psychiatry. 2021 Aug 1;78(8):876-885
pubmed: 34037667
Schizophr Bull. 2013 Jul;39(4):740-7
pubmed: 23671196
Psychiatry Res. 2001 May 10;102(1):65-72
pubmed: 11368841
Compr Psychiatry. 2011 Sep-Oct;52(5):479-85
pubmed: 21185016
Int J Methods Psychiatr Res. 2019 Mar;28(1):e1755
pubmed: 30426604
J Affect Disord. 2018 Jan 1;225:413-421
pubmed: 28850856
Schizophr Bull. 2014 May;40(3):504-15
pubmed: 24567502
Schizophr Bull. 2012 Mar;38(2):295-303
pubmed: 20603443
Assessment. 2004 Dec;11(4):330-41
pubmed: 15486169
Epidemiol Psychiatr Sci. 2019 Jun 07;29:e39
pubmed: 31172899
Ann Gen Psychiatry. 2013 Apr 27;12(1):13
pubmed: 23622559
BMJ Open. 2019 Feb 19;9(2):e025469
pubmed: 30782936
Encephale. 2021 Jun;47(3):215-220
pubmed: 33902898
Addiction. 2002 Sep;97(9):1183-94
pubmed: 12199834
Drugs. 2002;62(5):743-55
pubmed: 11929329
Compr Psychiatry. 2008 Sep-Oct;49(5):482-8
pubmed: 18702934
Acta Psychiatr Scand. 2011 Jul;124(1):18-29
pubmed: 21261599
Aust N Z J Psychiatry. 2002 Dec;36(6):733-42
pubmed: 12406115
Lancet Glob Health. 2018 Sep;6(9):e954-e955
pubmed: 30103990
Soc Psychiatry Psychiatr Epidemiol. 2004 Nov;39(11):927-37
pubmed: 15549247