The Combined Effects of a Methacrylate Powder Dressing (Altrazeal Powder) and Photobiomodulation Therapy on the Healing of a Severe Diabetic Foot Ulcer in a Diabetic Patient: A Case Report.

Altrazeal powder Diabetes mellitus Diabetic foot ulcer Photobiomodulation therapy Wound healing

Journal

Journal of lasers in medical sciences
ISSN: 2008-9783
Titre abrégé: J Lasers Med Sci
Pays: Iran
ID NLM: 101580415

Informations de publication

Date de publication:
2022
Historique:
received: 11 06 2022
accepted: 14 08 2022
entrez: 6 2 2023
pubmed: 7 2 2023
medline: 7 2 2023
Statut: epublish

Résumé

Weakened wound healing is a popular, severe complication of patients with diabetes which poses a risk for foot infection and amputation. Researchers have searched for new treatments for treating diabetic foot ulcers (DFUs) in recent years. In this case report, for the first time, we applied photobiomodulation therapy (PBMT) and Altrazeal powder together to treat a severe case of DFU in a 47-year-old woman who was suffering from type 1 diabetes. Along with the progress of combination therapy, we observed that the ulcer area was significantly reduced, and the wound healed within 16 weeks. Furthermore, dermatitis and purulent secretion were treated, and the pain was reduced. This reported case study indicated the beneficial effect of the combination of PBMT and Altrazeal powder for the healing of a severe DFU in a patient with type one diabetes. The combined application of PBMT plus Altrazeal powder demonstrated an additive effect. Further clinical trials in the clinical setting are suggested to validate the results further. Besides, more studies in preclinical models are suggested to find the mechanism of the action of combination therapy.

Identifiants

pubmed: 36743151
doi: 10.34172/jlms.2022.38
pmc: PMC9841389
doi:

Types de publication

Case Reports

Langues

eng

Pagination

e38

Informations de copyright

Copyright © 2022 J Lasers Med Sci.

Déclaration de conflit d'intérêts

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Références

Sci Rep. 2020 Jan 27;10(1):1206
pubmed: 31988386
J Cell Biochem. 2019 Oct;120(10):17994-18004
pubmed: 31148250
Front Physiol. 2018 May 01;9:419
pubmed: 29765329
Int Wound J. 2015 Jun;12(3):351-6
pubmed: 23919667
Biomaterials. 2019 Sep;216:119267
pubmed: 31247480
Diabetes Res Clin Pract. 2019 Nov;157:107843
pubmed: 31518657
Rev Col Bras Cir. 2014 Mar-Apr;41(2):129-33
pubmed: 24918727
Genes Dis. 2019 Sep 17;6(4):342-358
pubmed: 31832514
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Dec 5;262:120157
pubmed: 34271236
Int Wound J. 2009 Apr;6(2):133-9
pubmed: 19432662
Int J Mol Sci. 2017 Jul 17;18(7):
pubmed: 28714933
Curr Infect Dis Rep. 2018 Aug 1;20(10):40
pubmed: 30069605
Lasers Med Sci. 2022 Apr;37(3):1593-1604
pubmed: 34476655
BMJ Case Rep. 2018 Mar 15;2018:
pubmed: 29545429
Diabetes Care. 2018 Apr;41(4):645-652
pubmed: 29559450
J Photochem Photobiol B. 2019 Dec;201:111634
pubmed: 31715551
Lasers Med Sci. 2022 Feb;37(1):403-415
pubmed: 33738614
Diabetes Metab Res Rev. 2016 Jan;32 Suppl 1:246-53
pubmed: 26452233
J Lasers Med Sci. 2021 Jul 24;12:e40
pubmed: 34733763
Lasers Med Sci. 2011 Jan;26(1):125-31
pubmed: 20865435
BMJ Open Diabetes Res Care. 2020 Feb;8(1):
pubmed: 32098898
Lasers Surg Med. 2007 Dec;39(10):797-802
pubmed: 18081143
Int J Inflam. 2019 Jun 2;2019:3706315
pubmed: 31275545
Photomed Laser Surg. 2018 Jun;36(6):290-297
pubmed: 29882737
Adv Wound Care (New Rochelle). 2012 Aug;1(4):177-182
pubmed: 24527301
Int J Mol Sci. 2013 May 21;14(5):10582-90
pubmed: 23698780
Stem Cell Res Ther. 2020 Nov 25;11(1):494
pubmed: 33239072
Int Wound J. 2013 Dec;10 Suppl 1:25-31
pubmed: 24251841
AIMS Biophys. 2017;4(3):337-361
pubmed: 28748217

Auteurs

Roya Derakhshan (R)

Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.

Houssein Ahmadi (H)

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Mohammad Bayat (M)

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Price Institute of Surgical Research, University of Louisville, and Noveratech LLC, Louisville, KY, USA.

Leila Mehboudi (L)

Department of Anesthesia, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Erfan Pourhashemi (E)

School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Abdollah Amini (A)

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Dorsa Vatandoust (D)

Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Shahin Aghamiri (S)

Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Robabeh Asadi (R)

Department of Paramedicine, Tehran University of Medical Sciences, Tehran, Iran.

Babak Sabet (B)

Department of Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Classifications MeSH