Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia.
CAIX
biomarker
hypoxia
preeclampsia
pregnancy
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
10
2022
accepted:
02
01
2023
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
Preeclampsia (PE) is a severe complication of pregnancy. The identification of a reliable predictive biomarker could help in setting up a specific preventive strategy. To this aim, we studied carbonic anhydrase IX (CAIX) as a marker of hypoxia (a pathway involved in PE pathogenesis) and compared the diagnostic accuracy of CAIX to that of the validated biomarker sFlt1/PlGF ratio. Fifteen women with overt PE and 38 women at a risk of developing PE, sampled at different time intervals during gestation (a total of 82 plasma samples collected), were enrolled and underwent the CAIX measurement. CAIX levels significantly increased (
Identifiants
pubmed: 36743209
doi: 10.3389/fmolb.2023.1075604
pii: 1075604
pmc: PMC9892551
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1075604Informations de copyright
Copyright © 2023 Galbiati, Gabellini, Ambrosi, Soriani, Pasi, Locatelli, Lucianò, Candiani, Valsecchi, Zerbini and Smid.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hypertension. 2007 Apr;49(4):818-24
pubmed: 17261644
Pediatr Dev Pathol. 2015 Sep-Oct;18(5):380-6
pubmed: 26186234
Obstet Gynecol. 2008 Jun;111(6):1403-9
pubmed: 18515525
Nature. 2022 Jan;601(7893):422-427
pubmed: 34987224
Nephrol Dial Transplant. 2022 May 25;37(6):1109-1117
pubmed: 33950200
J Enzyme Inhib Med Chem. 2019 Dec;34(1):272-278
pubmed: 30734594
BMC Dev Biol. 2009 Mar 16;9:22
pubmed: 19291313
BMJ. 2019 Jul 15;366:l2381
pubmed: 31307997
Lancet. 2021 Jul 24;398(10297):341-354
pubmed: 34051884
Eur J Obstet Gynecol Reprod Biol. 2020 Feb;245:198-204
pubmed: 31889569
Int J Mol Sci. 2021 Feb 22;22(4):
pubmed: 33671527
Sci Rep. 2021 Mar 23;11(1):6674
pubmed: 33758274
Am J Obstet Gynecol. 2022 Feb;226(2S):S1019-S1034
pubmed: 33096092
Swiss Med Wkly. 2021 Jul 14;151:w20533
pubmed: 34283894
Hypertension. 2022 Feb;79(2):323-324
pubmed: 35020460
N Engl J Med. 2017 Aug 17;377(7):613-622
pubmed: 28657417
Pregnancy Hypertens. 2022 Mar;27:42-50
pubmed: 34915395
Hypertension. 2019 Oct;74(4):983-990
pubmed: 31401877
Oxid Med Cell Longev. 2019 Nov 4;2019:8238727
pubmed: 31781353
Am J Obstet Gynecol. 2018 Aug;219(2):147-161.e1
pubmed: 29454869
Oncotarget. 2012 Aug;3(8):759-73
pubmed: 22929622
Adv Clin Exp Med. 2018 Nov;27(11):1567-1572
pubmed: 30129291
Drug Discov Today. 2021 Nov;26(11):2754-2773
pubmed: 34302972
Clin Chem Lab Med. 2015 Aug;53(9):1339-47
pubmed: 25460285
BMC Pregnancy Childbirth. 2020 Feb 7;20(1):80
pubmed: 32033594
Hypertension. 2021 May 5;77(5):1430-1441
pubmed: 33775113
Obstet Gynecol. 2006 May;107(5):1103-13
pubmed: 16648417
J Am Coll Cardiol. 2020 Oct 6;76(14):1690-1702
pubmed: 33004135
Oncogene. 2010 Dec 16;29(50):6509-21
pubmed: 20890298
Reprod Biol Endocrinol. 2007 Feb 08;5:6
pubmed: 17288592