Transpulmonary generation of cell-free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms.
cell‐free hemoglobin
pulmonary arterial hypertension
vascular dysfunction
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
31
10
2022
revised:
12
12
2022
accepted:
03
01
2023
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
Circulating cell-free hemoglobin (CFH) is elevated in pulmonary arterial hypertension (PAH) and associated with poor outcomes but the mechanisms are unknown. We hypothesized that CFH is generated from the pulmonary circulation and inadequately cleared in PAH. Transpulmonary CFH (difference between wedge and pulmonary artery positions) and lung hemoglobin α were analyzed in patients with PAH and healthy controls. Haptoglobin genotype and plasma hemoglobin processing proteins were analyzed in patients with PAH, unaffected bone morphogenetic protein receptor type II mutation carriers (UMCs), and control subjects. Transpulmonary CFH was increased in patients with PAH (
Identifiants
pubmed: 36743426
doi: 10.1002/pul2.12185
pii: PUL212185
pmc: PMC9841468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12185Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL158906
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146588
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163960
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL157755
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL155891
Pays : United States
Informations de copyright
© 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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